John Noseworthy may refer to:

• Jack Noseworthy, born John Noseworthy, American actor
• John Noseworthy, a Canadian politician.
• John H. Noseworthy, neurologist and CEO of the Mayo Clinic
• John Noseworthy (English politician) (by 1481–1530/1532), English mayor and MP

• 3-2-1(song)
• 321st Artillery Regiment (United States)
• 321st Field Artillery Regiment
• 321st Field Artillery Regiment (United States)
• 321st Transport Squadron
• 321 Studios v. Metro Goldwyn Mayer Studios, Inc.
• 321 U.S. 1
• 321 U.S. 158
• 321 U.S. 414
• 321 U.S. 573
• 321 U.S. 649
• 3.2.1. (Zilch album)
• 3220 BC
• 3220s BC
• 3221 BC
• 3221 (number)
• 3222 BC
• 3222 symmetry
• 3223 BC
• 3224 BC
• 3225 BC
• 3225th Drone Squadron
• 3226 BC
• (322756) 2001 CK32
• 3227 BC