词条 | Julian Parkhill |
释义 |
| name = Julian Parkhill | birth_name = Julian Parkhill | native_name_lang = | image = Dr Julian Parkhill FMedSci FRS.jpg | image_size = | alt = | caption = Julian Parkhill in 2015 | birth_date = {{Birth date and age|df=yes|1964|09|23}}[1] | birth_place = Leigh-on-Sea[1] | other_names = | residence = | citizenship = | nationality = | fields ={{Plainlist|
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| thesis_title = Regulation of transcription of the mercury resistance operon of Tn501 | thesis_url = http://pmt-eu.hosted.exlibrisgroup.com/primo_library/libweb/action/display.do?doc=44BU_LMS_DS000519318&vid=44BU_VU1 | thesis_year = 1991 | doctoral_advisor = | academic_advisors = | doctoral_students = | notable_students = | known_for = ARTEMIS[2][3][4] | influences = | influenced = | awards = {{Plainlist|
| website = {{URL|sanger.ac.uk/people/directory/parkhill-julian}} | footnotes = | spouse = | children = }}Julian Parkhill (born 1964)[1] FRS[11] is a Head of Pathogen Genomics at the Wellcome Trust Sanger Institute[6][7][8][9][10][11][12] and an Honorary Professor of Microbial Genomics at the University of Cambridge.[13] EducationParkhill was educated at Westcliff High School for Boys,[1] the University of Birmingham and the University of Bristol where he was awarded a PhD in 1991[14] for research into the regulation of transcription of the mercury resistance operon.[15][16][17] ResearchParkhill uses high throughput sequencing and phenotyping to study pathogen diversity and variation, how they affect virulence and transmission, and what they tell us about the evolution of pathogenicity and host–pathogen interaction.[18][19][20][21][22][23][24][25][26][27][28][29][30] Research in the Parkill Laboratory has been funded the Wellcome Trust, the Biotechnology and Biological Sciences Research Council (BBSRC)[31] and the Medical Research Council (MRC).[32] Awards and honoursParkhill was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2009,[5] and a Fellow of the American Academy of Microbiology (FAAM) in 2012. {{centred pull quote|Dr. Julian Parkhill is currently Head of Pathogen Genomics at the Wellcome Trust Sanger Institute. Over the last decade or so, his group has analysed the genomes of many bacteria of fundamental importance for human health, including the causative agents of tuberculosis, plague, typhoid fever, whooping cough, leprosy, botulism, diphtheria and meningitis, as well as nosocomial pathogens such as Clostridium difficile and MRSA, and food-borne pathogens such as Campylobacter jejuni, Salmonella Typhimurium and Yersinia enterocolitica. Their current research focuses on the application of high-throughput sequencing techniques to microbiology. They are currently sequencing very large collections of bacterial isolates with broad geographic and temporal spreads, linking genomic variation to epidemiology, acquisition of drug resistance and recent evolution. In addition, they are working with local and national clinical microbiology groups to build the foundations for the transfer of microbial sequencing to clinical and public health investigations. They are also applying sequencing technologies to phenotypic investigations, particularly saturation transposon mutagenesis, transcriptomics and high-throughput phenotyping. They collaborate widely, particularly with groups in developing countries where infectious diseases are endemic.[33]}} Parkhill was elected a Fellow of the Royal Society (FRS) in 2014,[34] his certificate of election reads: {{centred pull quote|Julian Parkhill has played a major role in determining the reference genome sequences of many key bacterial pathogens, including Mycobacterium tuberculosis, Yersinia pestis and Salmonella typhi. As well as providing complete catalogues of the arsenal of genes carried by each bacterium, Parkhill's work has led to important insights into how bacterial genomes evolve and the effect of variation within supposedly homogeneous bacterial populations. In parallel, tools to understand and visualise genomic data have been developed, and freely disseminated worldwide. Over a decade, Parkhill has been at the forefront of bacterial genomics, most recently using new high throughput sequencing technologies to explore evolution and transmission in bacterial pathogens, and enable the clinical use of these approaches.[34]}} References{{Scholia|author}}1. ^1 2 3 {{Who's Who | surname = PARKHILL | othernames = Dr Julian | id = U281946 | volume = 2015 | edition = online Oxford University Press}} {{subscription required}} {{FRS 2014}}{{Authority control}}{{DEFAULTSORT:Parkhill, Julian}}2. ^{{Cite journal| doi=10.1093/bioinformatics/16.10.944| pmid=11120685| title=Artemis: Sequence visualization and annotation| journal=Bioinformatics| volume=16| issue=10| pages=944–5| year=2000| last1=Rutherford| first1=K.| last2=Parkhill| first2=J.| last3=Crook| first3=J.| last4=Horsnell| first4=T.| last5=Rice| first5=P.| last6=Rajandream| first6=M.-A.| last7=Barrell| first7=B.}} 3. ^{{Cite journal | pmid = 18845581| year = 2008| author1 = Carver| first1 = T| title = Artemis and ACT: Viewing, annotating and comparing sequences stored in a relational database| journal = Bioinformatics| volume = 24| issue = 23| pages = 2672–6| last2 = Berriman| first2 = M| last3 = Tivey| first3 = A| last4 = Patel| first4 = C| last5 = Böhme| first5 = U| last6 = Barrell| first6 = B. G.| last7 = Parkhill| first7 = J| last8 = Rajandream| first8 = M. A.| doi = 10.1093/bioinformatics/btn529| pmc = 2606163}} 4. ^{{Cite journal | last1 = Carver | first1 = T. | last2 = Harris | first2 = S. R. | last3 = Berriman | first3 = M. | last4 = Parkhill | first4 = J. | last5 = McQuillan | first5 = J. A. | title = Artemis: An integrated platform for visualization and analysis of high-throughput sequence-based experimental data | doi = 10.1093/bioinformatics/btr703 | journal = Bioinformatics | volume = 28 | issue = 4 | pages = 464–469 | year = 2011 | pmid = 22199388 | pmc =3278759 }} 5. ^1 {{cite web|url=https://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-julian-parkhill/ |title=Fellow | Academy of Medical Sciences |website=Acmedsci.ac.uk |accessdate=2016-11-18}} 6. ^{{cite web|archiveurl=https://web.archive.org/web/20160315093803/http://www.sanger.ac.uk/people/directory/parkhill-julian|archivedate=2016-03-15|url=http://www.sanger.ac.uk/people/directory/parkhill-julian|title=Professor Julian Parkhill, FRS, FMedSci, Senior Group Leader}} 7. ^{{Cite journal | doi = 10.1038/nrmicro3112| pmid = 23979431| title = What has high-throughput sequencing ever done for us?| journal = Nature Reviews Microbiology| volume = 11| issue = 10| pages = 664–5| year = 2013| last1 = Parkhill | first1 = J.}} 8. ^{{AcademicSearch|723091}} 9. ^{{DBLP |name=Julian Parkhill}} 10. ^1 {{Google Scholar id}} 11. ^{{Scopus}} 12. ^{{YouTube |id=M_Tj6p_8PfU|title=Professor Julian Parkhill visits the Wellcome Collection in London to unravel the Science behind the genome}} 13. ^{{cite journal|archiveurl=https://web.archive.org/web/20150315225606/https://www.admin.cam.ac.uk/reporter/2014-15/special/05/section7.shtml|archivedate=2015-03-15|url=https://www.admin.cam.ac.uk/reporter/2014-15/special/05/section7.shtml|journal=Cambridge University Reporter|title= Honorary Professors|publisher=University of Cambridge|date=12 December 2014|volume=CXLV|issue=5}} 14. ^{{cite thesis |degree=PhD |first=Julian|last=Parkhill |title=Regulation of transcription of the mercury resistance operon of Tn501 |publisher=University of Bristol |year=1991 |url=http://search.proquest.com/docview/301408708|oclc=931563576}}{{subscription required}} 15. ^1 {{Cite journal | pmid = 2169606| year = 1990| author1 = Parkhill| first1 = J| title = Site-specific insertion and deletion mutants in the mer promoter-operator region of Tn501; the nineteen base-pair spacer is essential for normal induction of the promoter by MerR| journal = Nucleic Acids Research| volume = 18| issue = 17| pages = 5157–62| last2 = Brown| first2 = N. 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O. | last27 = Goldstein | first27 = P. | last28 = Guralnick | first28 = R. | last29 = Haft | first29 = D. | last30 = Hancock | first30 = D. | display-authors = 29 | pmc=2409278}} 31. ^{{cite web|archiveurl=https://web.archive.org/web/20160304034459/http://www.bbsrc.ac.uk/research/grants-search/PersonDetails/?Personid=104217|archivedate=2016-03-04|url=http://www.bbsrc.ac.uk/research/grants-search/PersonDetails/?Personid=104217|publisher=BBSRC|title=Grants awarded to Julian Parkhill by the BBSRC|author=Anon|year=2014}} 32. ^{{cite web|archiveurl=https://web.archive.org/web/20150421112455/http://gtr.rcuk.ac.uk/person/236D4E9F-1D21-4C1B-A859-7A8128054A0C|archivedate=2015-04-21|url=http://gtr.rcuk.ac.uk/person/236D4E9F-1D21-4C1B-A859-7A8128054A0C|title=UK Government grants awarded to Julian Parhill|author=Anon|year=2014|publisher=Research Councils UK|location=Swindon}} 33. ^1 {{cite web|url=http://academy.asm.org/index.php/fellows-info/fellows-elected-in-2012/336-julian-parkhill |title=Julian Parkhill |website=Academy.asm.org |accessdate=2016-11-18}} 34. ^1 2 3 {{cite web|archiveurl=https://web.archive.org/web/20151117101946/https://royalsociety.org/people/julian-parkhill-12046/ |archivedate=2015-11-17 |author=Anon |year=2014 |url=https://royalsociety.org/people/julian-parkhill-12046/ |publisher=Royal Society |location=London |title=Professor Julian Parkhill FMedSci FRS }} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{quote|"All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --{{cite web|url=https://royalsociety.org/about-us/terms-conditions-policies/ |title=Royal Society Terms, conditions and policies |accessdate=2016-03-09 |deadurl=bot: unknown |archiveurl=https://web.archive.org/web/20150925220834/https://royalsociety.org/about-us/terms-conditions-policies/ |archivedate=2015-09-25 |df= }}}} 5 : Fellows of the Royal Society|Living people|Academics of the University of Birmingham|People educated at Westcliff High School for Boys|1964 births |
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