| 词条 | Julie Makani |
| 释义 |
|name = Julie Makani |image = |birth_date = {{birth year and age|1970}} |birth_place = |death_date = |death_place = |residence = Tanzania |nationality = Tanzanian |field = Medical research |work_institutions = Muhimbili University of Health and Allied Sciences |alma_mater = |awards = Royal Society Pfizer Award, 2011 }}{{external media | width = 210px | align = right | headerimage= | video1 = [https://www.youtube.com/watch?v=sd17odE1YLs#t=95 "By the time I started working two of my cousins had already died from sickle cell anemia", Royal Society Pfizer Award 2011]}}Julie Makani (born 1970) is a Tanzanian medical researcher. From 2014 she is Wellcome Trust Research Fellow and Associate Professor in the Department of Haematology and Blood Transfusion at the Muhimbili University of Health and Allied Sciences (MUHAS). Also a visiting fellow and consultant to the Nuffield Department of Medicine, University of Oxford, she is based in Dar es Salaam, Tanzania.[1] In 2011, she received the Royal Society Pfizer Award for her work with sickle cell disease.[2] EducationAfter attending St Constantine's Primary school in Arusha, Tanzania,[3] Makani trained in medicine in Tanzania at Muhimbili University, receiving her medical degree in 1994.[3] In 1997, she attended post-graduate studies in internal medicine at the Hammersmith Hospital, Royal Postgraduate Medical School, University of London, on a Commonwealth scholarship.[4] From there she went to Oxford as a Research Fellow at Nuffield Department of Medicine, University of Oxford.[1] She received a four-year PhD training fellowship from the Wellcome Trust in 2003 to study sickle cell disease in Tanzania. She completed her PhD on the clinical epidemiology of sickle cell disease (SCD).[5] Biomedical researchIn 2004, she received a Wellcome Trust training fellowship and established the Sickle Cell Disease (SCD) programme at Muhimbili University of Health and Allied Sciences (MUHAS), with prospective surveillance of over 2,000 SCD patients.[6] In sickle cell disease, red blood cells are abnormally shaped, causing problems with the flow of blood through the body and the resulting transport of oxygen throughout the body. A genetic disorder, the disease causes reoccurring episodes of pain and severe organ damage which can result in death.[7] An estimated eight to eleven thousand children per year are born with sickle-cell disease in Tanzania.[8] The focus of Makani's initial work at Muhimbili was to examine factors such as malaria, bacterial infections and stroke, which are considered to significantly contribute to illness and death when interventions are available.[9] In collaboration with colleagues, she has developed a biomedical research and healthcare programme which is one of the largest SCD cohorts from one centre in the world.[6] Her current interest is in the role of anaemia and foetal haemoglobin in influencing disease burden in SCD.[10] Makani is working with colleagues to establish networks at a national level in the regional Sickle Cell Disease Research Network of East and Central Africa (REDAC) and Africa (Sickle CHARTA – Consortium for Health, Advocacy, Research and Training in Africa).[7] Makani is co-founder of the Sickle Cell Foundation of Tanzania.[11] On a global level she is on the technical advisory group of Global SCD Research Network, co-chairing the working group responsible for hydroxyurea therapy in Africa.[7] Her aim is to use sickle cell disease as a model to establish scientific and healthcare solutions in Africa that are locally relevant as well as having global significance. Achieving success in sickle cell disease will illustrate that with effective global partnerships, inequities in biomedical science and health can be addressed and significant advances can be achieved.[12] Fellowships and other awardsMakani received a training (2003) and intermediate fellowship (2011) from the Wellcome Trust for the sickle cell disease programme.[6] In 2007, she received a fellowship to attend the TEDGlobal meeting in Arusha, Tanzania. In 2009, she received an Archbishop Tutu Leadership Fellowship from the African Leadership Institute.[13] In 2011 she was awarded The Royal Society Pfizer Award. The award grant will be used for research to provide a better understanding of the molecular, genetic and environmental mechanisms of sickle cell disease. In granting the award, Professor Lorna Casselton of the Royal Society, said: "We are extremely pleased to recognise such an impressive individual with the Royal Society Pfizer Award this year... We hope that Dr Makani stands as role-model for other young Africans scientists wishing to make a difference on their continent and worldwide."[2] References1. ^1 {{cite web|title=Dr Julie Makani|url=http://www.ndm.ox.ac.uk/principal-investigators/researcher/julie-makani|publisher=Nuffield Department of Medicine|accessdate=20 March 2014}} 2. ^1 {{cite news|title=Tanzanian scientist wins Royal Society Pfizer Award for Sickle Cell Disease research|url=http://royalsociety.org/news/Tanzanian-scientist-Pfizer-Award/|accessdate=20 March 2014|newspaper=The Royal Society|date=15 September 2011}} 3. ^{{cite news|title=DR JULIE MAKANI: Feeling the pain of sickle cell anaemia|url=http://www.africareview.com/Special-Reports/-/979182/1378568/-/w1cjs8z/-/index.html|accessdate=20 March 2014|newspaper=Africa Review|date=2 April 2012}} 4. ^1 {{cite news|last=Mwangi|first=Tabitha|title=Painful crisis: Dr Julie Makani’s fight against sickle cell disease|url=http://mobile.theeastafrican.co.ke/Magazine/Dr-Julie-Makanis-fight-against-sickle-cell-disease-/-/433852/1268200/-/format/xhtml/item/1/-/rl4ipaz/-/index.html|accessdate=20 March 2014|newspaper=The East African Magazine|date=6 November 2011}} 5. ^{{cite web|title=Dr Julie Makani - Principal Investigator (Haematology)|url=http://www.muhimbili-wellcome.org/index.php/profile?view=employee&id=1|publisher=Muhimbili Wellcome Programme|accessdate=20 March 2014}} 6. ^1 2 {{cite web|title=Muhimbili Wellcome Programme|url=http://www.muhimbili-wellcome.org/|publisher=Muhimbili Wellcome Programme|accessdate=20 March 2014}} 7. ^1 2 {{cite news|last=Sangare|first=Nene|title=FABA (For Africa By Africans): Sickle Cell Disease Research|url=http://www.africastrictlybusiness.com/news-analysis/faba-africa-africans-sickle-cell-disease-research|accessdate=20 March 2014|newspaper=Africa Strictly Business}} 8. ^{{cite news| last = Gribbin | first = Alice| url = http://www.newstatesman.com/health/2012/01/sickle-cell-disease-interview| title = The NS Interview: Julie Makani, tropical medicine researcher | publisher = New Statesman| accessdate = 18 March 2014}} 9. ^{{cite journal|last=Makani|first=Julie|author2=Kirkham, Fenella J. |author3=Komba, Albert |author4=Ajala-Agbo, Tolulope |author5=Otieno, Godfrey |author6=Fegan, Gregory |author7=Williams, Thomas N. |author8=Marsh, Kevin |author9= Newton, Charles R. |title=Risk factors for high cerebral blood flow velocity and death in Kenyan children with Sickle Cell Anaemia: role of haemoglobin oxygen saturation and febrile illness|journal=British Journal of Haematology|date=May 2009|volume=145|issue=4|pages=529–532|doi=10.1111/j.1365-2141.2009.07660.x |pmid=19344425 |pmc=3001030}} 10. ^{{cite journal|last=Makani|first=J. |author2=Menzel, S. |author3=Nkya, S. |author4=Cox, S. E. |author5=Drasar, E. |author6=Soka, D. |author7=Komba, A. N. |author8=Mgaya, J. |author9=Rooks, H. |author10=Vasavda, N. |author11=Fegan, G. |author12=Newton, C. R. |author13=Farrall, M. |author14=Lay Thein, S. |title=Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia|journal=Blood|date=10 November 2010|volume=117|issue=4|pages=1390–1392|doi=10.1182/blood-2010-08-302703|url=http://bloodjournal.hematologylibrary.org/content/117/4/1390.full.pdf|accessdate=20 March 2014 |pmid=21068433|pmc=5555384 }} 11. ^{{cite web|title=Sickle Cell Foundation of Tanzania |url=http://lms.muhas.ac.tz/sicklecelltz/ |accessdate=20 March 2014 |deadurl=yes |archiveurl=https://web.archive.org/web/20131126104350/http://lms.muhas.ac.tz/sicklecelltz/ |archivedate=26 November 2013 |df= }} 12. ^{{cite web|title=Julie Makani biography|url=http://www.globalsicklecelldisease.org/OurLeaders/juliemakani/index.aspx|publisher=Global Sickle Cell Disease Network|accessdate=20 March 2014}} 13. ^{{cite web|title=The Archbishop Desmond Tutu Leadership Fellowship Program|url=http://lanredahunsi.wordpress.com/2009/10/26/the-archbishop-desmond-tutu-leadership-fellowship-program/|publisher=The Personal Blog of Lanre Dahunsi|accessdate=20 March 2014|date=2009-10-26}} External links
5 : Living people|1970 births|Alumni of the University of London|Tanzanian hematologists|Women medical researchers |
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