| 词条 | JWH-048 |
| 释义 |
| IUPAC_name = (1-pentyl-2-methyl-1H-indol-3-yl)(7-methyl-1-naphthalenyl)methanone | image = JWH-048.png | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 316189-66-9 | ATC_prefix = | ATC_suffix = | PubChem = | DrugBank_Ref = | DrugBank = | ChemSpiderID = 9455134 | C=26 | H=27 | N=1 | O=1 | molecular_weight = 369.50 g/mol | smiles = CCCCCN1C(=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=C3C=C(C=C4)C)C | StdInChI = 1S/C26H27NO/c1-4-5-8-16-27-19(3)25(22-11-6-7-13-24(22)27)26(28)21-12-9-10-20-15-14-18(2)17-23(20)21/h6-7,9-15,17H,4-5,8,16H2,1-3H3 | StdInChIKey = HSGMJSSWGKDWNA-UHFFFAOYSA-N }}JWH-048 is a selective cannabinoid ligand, with a bindining affinity of Ki = 0.5 ± 0.1 nM for the CB2 subtype, and more than 22 times selectivity over the CB1.[1] See also
References1. ^{{cite journal |vauthors=Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR | title = Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding | journal = Drug and Alcohol Dependence | volume = 60 | issue = 2 | pages = 133–40 | year = 2000 | month = | pmid = 10940540| doi = 10.1016/S0376-8716(99)00152-0 }} {{Cannabinoids}}{{cannabinoid-stub}} 2 : Naphthoylindoles|JWH cannabinoids |
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