| 词条 | JWH-116 |
| 释义 |
| IUPAC_name = (2-ethyl-1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone | image = JWH-116.png | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = Schedule II | legal_UK = Class B | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 619294-64-3 | ATC_prefix = | ATC_suffix = | PubChem = | DrugBank_Ref = | DrugBank = | UNII = RKP962UAI3 | UNII_Ref = {{fdacite|correct|FDA}} | ChemSpiderID = 29341485 | C=26 | H=27 | N=1 | O=1 | molecular_weight = 369.50 g/mol | smiles = CCCCCN1C2=CC=CC=C2C(=C1CC)C(=O)C3=CC=CC4=CC=CC=C43 | StdInChI = 1S/C26H27NO/c1-3-5-10-18-27-23(4-2)25(22-15-8-9-17-24(22)27)26(28)21-16-11-13-19-12-6-7-14-20(19)21/h6-9,11-17H,3-5,10,18H2,1-2H3 | StdInChIKey = AQHPTHKEKSWGPO-UHFFFAOYSA-N }}JWH-116 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the indole 2-ethyl derivative of related compound JWH-018. The binding affinity of JWH-116 for the CB1 receptor is reported as Ki = 52 ± 5 nM.[1] See also
References1. ^{{cite journal |vauthors=Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR | title = 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor | journal = Bioorg. Med. Chem. | volume = 11 | issue = 4 | pages = 539–549 | year = 2003 | month = | pmid = 12538019| doi = 10.1016/s0968-0896(02)00451-0}} {{Cannabinoids}}{{cannabinoid-stub}} 4 : JWH cannabinoids|Naphthoylindoles|Phenol ethers|Designer drugs |
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