| 词条 | JWH-120 |
| 释义 |
| IUPAC_name = (4-methyl-1-naphthalenyl)(1-propyl-1H-indol-3-yl)methanone | image = JWH-120.png | tradename = | legal_status = | routes_of_administration = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 824955-98-8 | PubChem = 11461586 | ChemSpiderID = 9636426 | ChEMBL = 497811 | C=23 | H=21 | N=1 | O=1 | molecular_weight = 327.42 g/mol | smiles = CCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=C(C4=CC=CC=C43)C | StdInChI = 1S/C23H21NO/c1-3-14-24-15-21(19-10-6-7-11-22(19)24)23(25)20-13-12-16(2)17-8-4-5-9-18(17)20/h4-13,15H,3,14H2,1-2H3 | StdInChIKey = DUBUGSKBMMXSOU-UHFFFAOYSA-N }}JWH-120 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-propyl analog of JWH-122. It is a potent and selective ligand for the CB2 receptor, with a binding affinity of Ki = 6.1 ± 0.7 nM at this subtype, and 173 times selectivity over the CB1 subtype.[1] See also
References1. ^{{Cite journal |doi= 10.1016/j.bmc.2004.09.050 |pmid= 15582455 |year= 2005 |last= Huffman |first= J.|title= Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists. |volume= 13 |issue= 1 |pages= 89–112 |journal= Bioorganic & Medicinal Chemistry |display-authors=etal}} {{Cannabinoids}}{{cannabinoid-stub}} 3 : Cannabinoids|JWH cannabinoids|Naphthoylindoles |
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