| 词条 | JWH-193 |
| 释义 |
| verifiedrevid = 451605875 | IUPAC_name = (1-(2-morpholin-4-ylethyl)indol-3-yl)-4-methylnaphthalen-1-ylmethanone | image = JWH-193.svg | width = 220 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = Schedule II | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 133438-58-1 | ATC_prefix = | ATC_suffix = | PubChem = 10250276 | UNII = WB1TIJ1IO9 | UNII_Ref = {{fdacite|correct|FDA}} | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID = 8425762 | C=26 | H=26 | N=2 | O=2 | molecular_weight = 398.496 g/mol | smiles = c3cccc1c3c(ccc1C)C(=O)c5c2ccccc2n(c5)CCN4CCOCC4 | StdInChI = 1S/C26H26N2O2/c1-19-10-11-23(21-7-3-2-6-20(19)21)26(29)24-18-28(25-9-5-4-8-22(24)25)13-12-27-14-16-30-17-15-27/h2-11,18H,12-17H2,1H3 | StdInChIKey = ICKWPPYMDARCKJ-UHFFFAOYSA-N }}JWH-193 is a drug from the aminoalkylindole family which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-193 has a binding affinity at the CB1 receptor of 6nM, binding around seven times more tightly than the parent compound JWH-200,[1] though with closer to twice the potency of JWH-200 in activity tests. A structural isomer of JWH-193 with the methyl group on the indole ring instead of the naphthoyl ring, was also found to be of similarly increased potency over JWH-200.[2][3]{{clear-left}} See also
References1. ^Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411. {{Cannabinoids}}{{cannabinoid-stub}}2. ^{{cite journal |vauthors=Eissenstat MA, etal |title=Aminoalkylindoles: structure-activity relationships of novel cannabinoid mimetics |journal=Journal of Medicinal Chemistry |volume=38 |issue=16 |pages=3094–105 |date=August 1995 |pmid=7636873 |doi= 10.1021/jm00016a013 }} 3. ^{{cite journal |vauthors=Shim JY, etal |title=Three-dimensional quantitative structure-activity relationship study of the cannabimimetic (aminoalkyl)indoles using comparative molecular field analysis |journal=Journal of Medicinal Chemistry |volume=41 |issue=23 |pages=4521–32 |date=November 1998 |pmid=9804691 |doi=10.1021/jm980305c }} 5 : JWH cannabinoids|Aminoalkylindoles|Naphthoylindoles|Morpholines|Designer drugs |
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