| 词条 | JWH-302 |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 477496206 | IUPAC_name = 2-(3-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone | image = JWH-302.svg | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 864445-45-4 | ATC_prefix = | ATC_suffix = | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 186674 | PubChem = 11493740 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 9668546 | C=22 | H=25 | N=1 | O=2 | molecular_weight = 335.439 g/mol | smiles = c2ccc(OC)cc2CC(=O)c(cn1CCCCC)c3ccccc13 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C22H25NO2/c1-3-4-7-13-23-16-20(19-11-5-6-12-21(19)23)22(24)15-17-9-8-10-18(14-17)25-2/h5-6,8-12,14,16H,3-4,7,13,15H2,1-2H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = XZVYWLVYUAQEIM-UHFFFAOYSA-N }}JWH-302 or (1-pentyl-3-(3-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist with moderate affinity at both the CB1 and CB2 receptors. It is a positional isomer of the more common drug JWH-250, though it is slightly less potent with a Ki of 17 nM at CB1, compared to 11 nM for JWH-250.[1][2] Because of their identical molecular weight and similar fragmentation patterns, JWH-302 and JWH-250 can be very difficult to distinguish by GC-MS testing.[3] References1. ^{{cite journal |author= Huffman, JW.|title= 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles |journal= Bioorganic & Medicinal Chemistry Letters |volume= 15 |issue= 18 |pages= 4110–3 |year= 2005 |pmid= 16005223 |doi= 10.1016/j.bmcl.2005.06.008 |display-authors=etal}} {{Cannabinoids}}{{Cannabinoid-stub}}2. ^{{cite journal |last1= Manera |first1= C |last2= Tuccinardi |first2= T |last3= Martinelli |first3= A |title= Indoles and related compounds as cannabinoid ligands |journal= Mini Reviews in Medicinal Chemistry |volume= 8 |issue= 4 |pages= 370–87 |year= 2008 |pmid= 18473928 |doi=10.2174/138955708783955935}} 3. ^'Herbal High' synthetic Cannabinoid composition, released by ESR July 2011 3 : JWH cannabinoids|Phenylacetylindoles|Phenol ethers |
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