K16 may refer to:

• HMS K16, a 1916 K class submarine
• K-16 (Kansas highway), a state highway in Kansas
• K–16, a movement in the United States to bring together the various levels of education for younger students
• Kelsey K-16, an American, strut-braced, high-wing, two-seat, glider
• Seoul Air Base, designated as K-16 by the United States Air Force
• Symphony No. 1 (Mozart), K. 16, by Wolfgang Amadeus Mozart

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