| 词条 | Kallikrein 8 |
| 释义 |
| Name = Kallikrein 8 | EC_number = 3.4.21.118 | CAS_number = 171715-15-4 | IUBMB_EC_number = 3/4/21/118 | GO_code = | image = | width = | caption = }}Kallikrein 8 ({{EC number|3.4.21.118}}, KLK8, PRSS19, human kallikrein 8, hK8, mK8, ovasin, tumor-associated differentially expressed gene 14, TADG-14, NP, neuropsin) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys The enzyme is activated by removal of an N-terminal prepropeptide. References1. ^{{cite journal | vauthors = Chen ZL, Yoshida S, Kato K, Momota Y, Suzuki J, Tanaka T, Ito J, Nishino H, Aimoto S, Kiyama H | title = Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus | journal = The Journal of Neuroscience | volume = 15 | issue = 7 Pt 2 | pages = 5088–97 | date = July 1995 | pmid = 7623137 | doi = 10.1523/JNEUROSCI.15-07-05088.1995 }} 2. ^{{cite journal | vauthors = Shimizu C, Yoshida S, Shibata M, Kato K, Momota Y, Matsumoto K, Shiosaka T, Midorikawa R, Kamachi T, Kawabe A, Shiosaka S | title = Characterization of recombinant and brain neuropsin, a plasticity-related serine protease | journal = The Journal of Biological Chemistry | volume = 273 | issue = 18 | pages = 11189–96 | date = May 1998 | pmid = 9556608 | doi = 10.1074/jbc.273.18.11189 }} 3. ^{{cite journal | vauthors = Rajapakse S, Ogiwara K, Takano N, Moriyama A, Takahashi T | title = Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins | journal = FEBS Letters | volume = 579 | issue = 30 | pages = 6879–84 | date = December 2005 | pmid = 16337200 | doi = 10.1016/j.febslet.2005.11.039 }} 4. ^{{cite journal | vauthors = Kishi T, Cloutier SM, Kündig C, Deperthes D, Diamandis EP | title = Activation and enzymatic characterization of recombinant human kallikrein 8 | journal = Biological Chemistry | volume = 387 | issue = 6 | pages = 723–31 | date = June 2006 | pmid = 16800733 | doi = 10.1515/BC.2006.091 }} External links
1 : EC 3.4.21 |
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