| 词条 | Kangri cancer |
| 释义 |
| name = | synonym = | image = | image_size = | alt = | caption = | pronounce = | specialty = Dermatology/oncology | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}Kangri cancer is a type of squamous-cell carcinoma of the skin. It is found only in Kashmir in the northwest of the Indian subcontinent. It occurs on the lower abdomen and inner thighs and is due to the use of a kanger, a ceramic pot covered with wicker-work, carried as a source of warmth during cold weather. One of the earliest records of the condition was made in 1881 by surgeons at the Kashmir Mission Hospital and its cause was recognized in the early 20th century by Arthur Neve.[1][2] Despite current knowledge of the cause of this condition, cases are still being reported.[3] Other conditions associated with prolonged use of kangri in this fashion include erythema ab igne, a reticulate hypermelanosis with erythema. Signs and symptomsMost cases (80%) of squamous cell carcinoma attributed to ultraviolet radiation present in areas of the skin that are usually more exposed to sunlight (e.g., head, face, neck).[4] Although a particular form of squamous cell carcinoma, Kangri cancer is more often associated with the abdomen, thigh, and leg regions due to the usage and positioning of kangri pots, which come in close contact with these anatomical features.[5][6] Over time, the use of Kangri pots to keep warm results in erythema ab igne, a precancerous keratotic growth that “take the shape of superficial, serpegenous, reticular blackish brown colored lesions.”[6] Eventually, the cells at the lesion site become more irregular in shape and form; the lesions “ulcerate” and may become itchy and bloody. The resulting irregular growth is the presentation of Kangri cancer.[4][6] Risk factorsUse of the kangri pot has been correlated with the risk of Kangri cancer. The pot holds hot wood and charcoal, and as a unit, the pot is put in direct contact with the skin of the abdomen and the thigh areas as a way to keep warm during winters in north India.[6] Elements that are believed to contribute to the development of Kangri cancer are heat, burning wood particles, smoke, soot, and tar of burnt chinar leaves that could also be used as a fuel source for burning in the production of heat.[7][8] In one study, researchers noted kangri pot usage patterns and found that Kangri cancer “patients gave the history of using the Kangri especially for 3-4 winter months [...] every year for 5-6 hours daily.”[9] GeneticsBeyond the behavioral risk factor of prolonged usage of Kangri pots, researchers have begun to look at genetic mutations that may make some people more predisposed to develop Kangri cancer.
Diagnosis{{Empty section|date=May 2018}}TreatmentSurgeryIn the treatment of Kangri cancer, surgery is, most often, the first-line course of action to remove the primary tumor.[6] RadiotherapyExternal beam radiotherapy has been used in one person to prevent the relapse and growth of tumor metastases to the head and neck regions. The prophylactic applications of radiation have been noted as “encouraging” in this one case, reducing some tumors and eliminating others.[6]Another study with a couple of the same authors found that radiotherapy after surgery helped with the reduction and cure of head and neck tumors in additional cases. The researchers suggest that external beam radiotherapy should be part of the treatment course for patients who have or at risk of developing tumors in the head and neck areas.[4] PrognosisA research article from 1923 notes that the “average duration of life” in those with Kangri cancer is about fifteen months, though there have been records of people dying within one year and living for more than twenty years with Kangri cancer.[7] Updated life expectancy is not found in more recent scientific publications. However, in 2013, it was noted that the progression from erythema ab igne to squamous cell carcinoma, manifesting as Kangri cancer, was between one to two decades.[9] It has been reported that about one-third to one-half of patients with Kangri cancer show metastasis to local lymph nodes.[4] EpidemiologyThe first case of Kangri cancer was reportedly recognized in 1819.[6] The incidence of Kangri cancer is higher for the elderly, those who are at least 50 years old.[4][9] There is no definitive predominance of Kangri cancer in either males or females. Some studies may point to higher prevalence in males while others observed higher prevalence in females.[4][9] In scientific literature, Kangri cancer has only been attributed to the Kashmir region of northern India due to the traditional use of kangri pots. Kangri cancer is limited to this population, and thus, relatively little is known still, and there is much to be studied about the condition.[6][9][10] In 2017, a local Kashmir media outlet,The Kashmir Reader, reported that researchers and health care providers are optimistic about the reduced incidence of Kangri cancer, citing the rise of thermal clothing and electric heating sources that are now used in place of kangri pots to keep warm.[12] See also
References1. ^Neve A (1900) Indian med. Gaz. 35, 81 2. ^{{cite journal | author = McCulloch HD | year = 1910 | title = 'Kangri cancer': A physiological aspect | url = | journal = Br Med J | volume = 2 | issue = 2595| pages = 912–913 |PMC=2336016 | doi=10.1136/bmj.2.2595.912-b}} 3. ^{{cite journal | author = Wani I | year = 2010 | title = Kangri cancer | url = | journal = Surgery | volume = 147 | issue = 4| pages = 586–588 | doi=10.1016/j.surg.2009.10.025}} 4. ^1 2 3 4 5 {{Cite journal|last=Teli|first=Mohmad Ashraf|last2=Khan|first2=N. A.|last3=Darzi|first3=M. Ashraf|last4=Gupta|first4=Meenu|last5=Tufail|first5=A.|date=2009-01-01|title=Recurrence pattern in squamous cell carcinoma of skin of lower extremities and abdominal wall (Kangri cancer) in Kashmir valley of Indian subcontinent: impact of various treatment modalities|journal=Indian Journal of Dermatology|volume=54|issue=4|pages=342–346|doi=10.4103/0019-5154.57610|issn=1998-3611|pmc=2807710|pmid=20101335}} 5. ^1 {{Cite journal|last=Hussain|first=Ishraq|last2=ul Rehman|first2=Shakeel|last3=Afroze|first3=Dil|last4=Zahoor|first4=Lubna|last5=Abdullah|first5=Safiya|last6=Hafiz|first6=Adil|last7=Shah|first7=Zafar A.|last8=Iqbal|first8=Shabir|last9=Shaffi|first9=Mohammad|date=2009-05-31|title=Mutational spectrum of conserved regions of TP53 and PTEN genes in Kangri cancer (of the skin) in the Kashmiri population|journal=Mutation Research|volume=676|issue=1-2|pages=5–10|doi=10.1016/j.mrgentox.2009.02.011|issn=0027-5107|pmid=19486858}} 6. ^1 2 3 4 5 6 7 {{Cite journal|last=Teli|first=Ma|last2=Darzi|first2=Ma|last3=Gupta|first3=M.|last4=Katoch|first4=Ss|date=2008-07-01|title=Recurrent Kangri cancer treated with external beam radiotherapy on a cobalt unit|journal=Indian Journal of Cancer|volume=45|issue=3|pages=134–135|issn=0019-509X|pmid=19018122|doi=10.4103/0019-509x.44074}} 7. ^1 {{Cite journal|last=Neve|first=E. F.|date=1923-12-29|title=KANGRI-BURN CANCER|journal=British Medical Journal|volume=2|issue=3287|pages=1255–1256|issn=0007-1447|pmc=2317796|pmid=20771404|doi=10.1136/bmj.2.3287.1255}} 8. ^{{Cite journal|last=Gothoskar|first=S. V.|last2=Ranadive|first2=K. J.|date=1966-12-01|title=Experimental studies on the aetiology of "Kangri cancer"|journal=British Journal of Cancer|volume=20|issue=4|pages=751–755|issn=0007-0920|pmc=2008146|pmid=5964606|doi=10.1038/bjc.1966.86}} 9. ^1 2 3 4 {{Cite journal|last=Hassan|first=Iffat|last2=Sajad|first2=Peerzada|last3=Reshi|first3=Ruby|date=2013-05-01|title=Histopathological analysis of the cutaneous changes due to kangri use in kashmiri population: a hospital based study|journal=Indian Journal of Dermatology|volume=58|issue=3|pages=188–190|doi=10.4103/0019-5154.110825|issn=1998-3611|pmc=3667279|pmid=23723467}} 10. ^1 {{Cite journal|last=Pandith|first=Arshad A.|last2=Khan|first2=Nighat P.|last3=Rashid|first3=Nargis|last4=Azad|first4=Niyaz|last5=Zaroo|first5=Inam|last6=Hafiz|first6=Adil|last7=Siddiqi|first7=Mushtaq A.|date=2012-08-01|title=Impact of codon 72 Arg > Pro single nucleotide polymorphism in TP53 gene in the risk of kangri cancer: a case control study in Kashmir|journal=Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine|volume=33|issue=4|pages=927–933|doi=10.1007/s13277-012-0318-2|issn=1423-0380|pmid=22249977}} 11. ^{{Cite journal|last=Rehman|first=Shakeel Ul|last2=Sameer|first2=A. Syed|last3=Zahoor|first3=Lubna|last4=Syeed|first4=Nidda|last5=Nanda|first5=Mahoor S.|last6=Hafiz|first6=Adil|last7=Shah|first7=Zaffar A.|last8=Siddiqi|first8=Mushtaq A.|date=2009-05-01|title=Polymorphic analysis of MHClinked Heat Shock Protein 70 genes: Their susceptibility and prognostic implication in Kangri cancer cases of Kashmiri population|journal=Indian Journal of Human Genetics|volume=15|issue=2|pages=65–71|doi=10.4103/0971-6866.55218|issn=0971-6866|pmc=2910951|pmid=20680154}} 12. ^{{Cite web|url=http://kashmirreader.com/2017/02/05/specific-to-kashmir-kangri-cancer-on-decline/|title=Specific to Kashmir, Kangri cancer on decline|last=Correspondent|first=Reader|date=2017-02-05|website=Kashmir Reader|access-date=2017-04-21}} External links
2 : Skin conditions resulting from physical factors|Diseases and disorders in India |
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