| 词条 | Kaolin clotting time |
| 释义 |
| name = Kaolin clotting time | image = | alt = | caption = | pronounce = | synonyms = | test of = Blood plasma[1] | reference_range = | calculator = | DiseasesDB = | ICD10 = | ICD9 = | ICDO = | MedlinePlus = | eMedicine = | MeshID = | OPS301 = | LOINC = }}Kaolin clotting time (KCT) is a sensitive test to detect lupus anticoagulants.[2] There is evidence that suggests it is the most sensitive test for detecting lupus anticoagulants.[3] It can also detect factor VIII inhibitors but is sensitive to unfractionated heparin as well.[4] HistoryKCT was first described by Dr. Margolis in 1958.[5] PrincipleKCT is similar to the activated partial thromboplastin time test, except it does not use exogenous phospholipid.[2] Thus, a confirmatory test that uses excess phospholipid is needed to validate the presence of lupus anticoagulants.[2] Kaolin is the surface activator, and the test also requires small amounts of cell fragments and plasma lipids to provide the phospholipid surface required for coagulation.[2][4] Therefore, the sample quality is important for the validity of the test.[2] MethodThe test combines a test plasma with kaolin, and the time the clot (in seconds) is measured.[5] InterpretationIf the KCT is less than 60 seconds, this suggests that the normal control plasma is contaminated with platelet fragments; therefore, the test is not valid.[4] The KCT test/control ratio of greater than or equal to 1.2 indicates an inhibitor is present.[4] If the test/control ratio is between 1.1 and 1.2, the test is equivocal.[4] See also
References1. ^{{cite book |last1=Gronowski |first1=Ann M. |title=Handbook of Clinical Laboratory Testing During Pregnancy |date=2004 |publisher=Springer Science & Business Media |isbn=9781592597871 |page=308 |url=https://books.google.ca/books?id=Dt_OBgAAQBAJ&pg=PA308 |language=en}} {{med-diagnostic-stub}}2. ^1 2 3 4 {{cite book | doi = 10.1007/978-1-62703-339-8_25 | pmid=23546725 | title=Kaolin Clotting Time | journal=Methods in Molecular Biology | volume=992 | date=2013 | pages=335–339 | first=Kottayam | last=Radhakrishnan| isbn=978-1-62703-338-1 }} 3. ^{{Cite journal | pmid = 2128977| year = 1990| author1 = Exner| first1 = T| title = Comparison of test methods for the lupus anticoagulant: International survey on lupus anticoagulants-I (ISLA-1)| journal = Thrombosis and Haemostasis| volume = 64| issue = 3| pages = 478–84| last2 = Triplett| first2 = D. A.| last3 = Taberner| first3 = D. A.| last4 = Howard| first4 = M. A.| last5 = Harris| first5 = E. N.}} 4. ^1 2 3 4 {{cite web |url=http://www.practical-haemostasis.com/Thrombophilia%20Tests/APS/kct.html/ |title=Kaolin Clotting Time [KCT] |accessdate=26 November 2014}} 5. ^1 {{Cite journal | pmid = 13575555| pmc = 479806| year = 1958| author1 = Margolis| first1 = J| title = The kaolin clotting time; a rapid one-stage method for diagnosis of coagulation defects| journal = Journal of Clinical Pathology| volume = 11| issue = 5| pages = 406–9}} 1 : Blood tests |
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