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词条 (KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase
释义

  1. References

  2. External links

{{Infobox enzyme
| Name = (KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase
| EC_number = 2.4.99.14
| CAS_number =
| IUBMB_EC_number = 2/4/99/14
| GO_code =
| image =
| width =
| caption =
}}(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase ({{EC number|2.4.99.14}}, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)2-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase ((2->8) glycosidic bond-forming).[1][2][3] This enzyme catalyses the following chemical reaction

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP

The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes.

References

1. ^{{cite journal | vauthors = Löbau S, Mamat U, Brabetz W, Brade H | title = Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-alpha-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183 | journal = Molecular Microbiology | volume = 18 | issue = 3 | pages = 391–9 | date = November 1995 | pmid = 8748024 | doi = 10.1111/j.1365-2958.1995.mmi_18030391.x }}
2. ^{{cite journal | vauthors = Mamat U, Baumann M, Schmidt G, Brade H | title = The genus-specific lipopolysaccharide epitope of Chlamydia is assembled in C. psittaci and C. trachomatis by glycosyltransferases of low homology | journal = Molecular Microbiology | volume = 10 | issue = 5 | pages = 935–41 | date = December 1993 | pmid = 7523826 | doi = 10.1111/j.1365-2958.1993.tb00965.x }}
3. ^{{cite journal | vauthors = Belunis CJ, Mdluli KE, Raetz CR, Nano FE | title = A novel 3-deoxy-D-manno-octulosonic acid transferase from Chlamydia trachomatis required for expression of the genus-specific epitope | journal = The Journal of Biological Chemistry | volume = 267 | issue = 26 | pages = 18702–7 | date = September 1992 | pmid = 1382060 }}

External links

  • {{MeshName|(KDO)2-lipid+IVA+(2-8)+3-deoxy-D-manno-octulosonic+acid+transferase}}
{{Glycosyltransferases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}

1 : EC 2.4.99

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