“(KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase”的意思、由来-开放百科全书

词条

(KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase

释义

References
External links

{{Infobox enzyme
| Name = (KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase
| EC_number = 2.4.99.15
| CAS_number =
| IUBMB_EC_number = 2/4/99/15
| GO_code =
| image =
| width =
| caption =
}}(KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase ({{EC number|2.4.99.15}}, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)3-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase ((2->4) glycosidic bond-forming).^[1]^[2] This enzyme catalyses the following chemical reaction

alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP

The enzyme from Chlamydia psittaci transfers four KDO residues to lipid A, forming a branched tetrasaccharide.

References

1. ^{{cite journal | vauthors = Brabetz W, Lindner B, Brade H | title = Comparative analyses of secondary gene products of 3-deoxy-D-manno-oct-2-ulosonic acid transferases from Chlamydiaceae in Escherichia coli K-12 | journal = European Journal of Biochemistry | volume = 267 | issue = 17 | pages = 5458–65 | date = September 2000 | pmid = 10951204 | doi = 10.1046/j.1432-1327.2000.01619.x }}
2. ^{{cite journal | vauthors = Holst O, Bock K, Brade L, Brade H | title = The structures of oligosaccharide bisphosphates isolated from the lipopolysaccharide of a recombinant Escherichia coli strain expressing the gene gseA [3-deoxy-D-manno-octulopyranosonic acid (Kdo) transferase] of Chlamydia psittaci 6BC | journal = European Journal of Biochemistry | volume = 229 | issue = 1 | pages = 194–200 | date = April 1995 | pmid = 7744029 | doi = 10.1111/j.1432-1033.1995.tb20455.x }}

External links

{{MeshName|(KDO)3-lipid+IVA+(2-4)+3-deoxy-D-manno-octulosonic+acid+transferase}}

1 : EC 2.4.99

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