| 词条 | KIN2/PAR-1/MARK kinase family |
| 释义 |
| Symbol = KA1 | Name = Kinase associated domain 1 | image = PDB 1ul7 EBI.jpg | width = | caption = solution structure of kinase associated domain 1 of mouse map/microtubule affinity-regulating kinase 3 | Pfam = PF02149 | Pfam_clan = | InterPro = IPR001772 | SMART = | PROSITE = | MEROPS = | SCOP = 1ul7 | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, members of the KIN2/PAR-1/MARK kinase family of proteins are kinases that are conserved from yeast to human and share the same domain organisation: an N-terminal kinase domain and a C-terminal kinase associated domain 1 (KA1). Some members of this family also contain an UBA domain (ubiquitin-associated domain). Members of this kinase family are involved in various biological processes such as cell polarity, cell cycle control, intracellular signalling, microtubule stability and protein stability.[1] The function of the KA1 domain is not yet known. Some proteins known to contain a KA1 domain are listed below:
References1. ^{{cite journal |vauthors=Tassan JP, Le Goff X | title = An overview of the KIN1/PAR-1/MARK kinase family | journal = Biol. Cell | volume = 96 | issue = 3 | pages = 193–9 |date=April 2004 | pmid = 15182702 | doi = 10.1016/j.biolcel.2003.10.009 | url = }} {{InterPro content|IPR001772}}{{DEFAULTSORT:KIN2 PAR-1 MARK kinase family}}2. ^{{cite journal |vauthors=Biernat J, Wu YZ, Timm T, Zheng-Fischhofer Q, Mandelkow E, Meijer L, Mandelkow EM | title = Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity | journal = Mol. Biol. Cell | volume = 13 | issue = 11 | pages = 4013–28 |date=November 2002 | pmid = 12429843 | pmc = 133611 | doi = 10.1091/mbc.02-03-0046 | url = }} 3. ^{{cite journal |vauthors=Guo S, Kemphues KJ | title = par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed | journal = Cell | volume = 81 | issue = 4 | pages = 611–20 |date=May 1995 | pmid = 7758115 | doi = 10.1016/0092-8674(95)90082-9| url = }} 4. ^{{cite journal |vauthors=Elbert M, Rossi G, Brennwald P | title = The yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machinery | journal = Mol. Biol. Cell | volume = 16 | issue = 2 | pages = 532–49 |date=February 2005 | pmid = 15563607 | pmc = 545889 | doi = 10.1091/mbc.E04-07-0549 | url = }} 1 : Protein domains |
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