| 词条 | Kirsanov reaction |
| 释义 |
The Kirsanov reaction is a method for the synthesis of certain organophosphorus compounds. In this reaction a tertiary phosphine is combined with a halogen and then an amine to give the iminophosphines, which are useful ligands and useful reagents.[1] A typical reaction involves triphenylphosphine with bromine to give bromotriphenylphosphonium bromide: Ph3P + Br2 → Ph3PBr+Br− This salt is treated in situ with alkylamines to give the iminophosphorane: Ph3PBr+Br− + 3 RNH2 → Ph3PNR + 2 RNH3+Br− The method is used when the conventional Staudinger reaction is not applicable, i.e. when the organic azide is not available to generate the iminophosphorane. Thus, it is used to make iminophosphoranes from alkyl amines.[2] References1. ^{{cite journal|last1=Eguchi|first1=Shoji|last2=Matsushita|first2=Yuji|last3=Yamashita|first3=Keizo|title=THE AZA-WITTIC REACTION IN HETEROCYCLIC SYNTHESIS. A REVIEW|journal=Organic Preparations and Procedures International|date=April 1992|volume=24|issue=2|pages=209–243|doi=10.1080/00304949209355702}} 2. ^{{cite journal|last1=Buchard|first1=Antoine|last2=Heuclin|first2=Hadrien|last3=Auffrant|first3=Audrey|last4=Le Goff|first4=Xavier F.|last5=Le Floch|first5=Pascal|title=Coordination of tetradentate X2N2 (X = P, S, O) ligands to iron(ii) metal center and catalytic application in the transfer hydrogenation of ketones|journal=Dalton Transactions|date=2009|issue=9|pages=1659|doi=10.1039/b816439h}} 1 : Name reactions |
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