KPLK may refer to:

• KPLK (FM), a radio station (88.9 FM) licensed to serve Sedro-Woolley, Washington, United States
• M. Graham Clark Downtown Airport (ICAO code KPLK)

• TCDD 56301 Class
• TCDD 56501 Class
• TCDD 5701 Class
• TCDD DE22000
• TCDD DE24000
• TCDD DE33000
• TCDD DH7000
• TCDD MT5600
• TCDO
• TCDSB
• TCDT
• T. C. Eastick
• TCEB1
• TCEB2
• TC Electronic
• T-Cell
• T cell activation
• T-cell antigen receptors
• T-cell leukemia
• T-cell lymphoma
• T-cell lymphoma invasion and metastasis-inducing protein 1
• T-cell lymphomas
• T-cell prolymphocytic leukemia
• T-cell receptors
• T-Cells