| 词条 | KSR2 |
| 释义 |
The KSR2 gene (also called "The fat gene"){{citation needed|date=January 2017}} is Kinase suppressor of ras 2 it is a protein that in humans is encoded by the KSR2 gene.[1] KSR2 mutation effects in humans by obesity and because KSR2 gene reduces the ERK signaling and it reduces glucose and fatty acid oxidation. KSR2 mutation reduces the glucose and fatty acid oxidation process but it makes growth factor "Epidermal growth factor (EGF)" reaction more faster to simulate cell growth and KSR2 cause insulin resistance, KSA2 gene also regulates how the body uses the energy, and it usually causes type 2 diabetes.[2] References1. ^{{cite web | title = KSR2 | url = https://www.ncbi.nlm.nih.gov/gene/283455 | work = Entrez Gene }} {{Serine/threonine-specific protein kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}2. ^{{cite journal | vauthors = Pearce LR, Atanassova N, Banton MC, Bottomley B, van der Klaauw AA, Revelli JP, Hendricks A, Keogh JM, Henning E, Doree D, Jeter-Jones S, Garg S, Bochukova EG, Bounds R, Ashford S, Gayton E, Hindmarsh PC, Shield JP, Crowne E, Barford D, Wareham NJ, O'Rahilly S, Murphy MP, Powell DR, Barroso I, Farooqi IS | display-authors = 6 | title = KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation | journal = Cell | volume = 155 | issue = 4 | pages = 765–77 | date = November 2013 | pmid = 24209692 | pmc = 3898740 | doi = 10.1016/j.cell.2013.09.058 | authorlink26 = Sadaf Farooqi }} 3 : Genes|Human proteins|EC 2.7.11 |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。