| 词条 | Kurt Julius Isselbacher |
| 释义 |
|name = Kurt Julius Isselbacher |image = File:Kurt Isselbacher.jpg |image_size = |caption = Dr. Kurt J. Isselbacher, M.D. |birth_date = {{Birth date and age|1925|09|12}} |birth_place = Wirges, Germany. |years_active = 1988-present |occupation = Director Emeritus, Massachusetts General Hospital Cancer Center |spouse = {{marriage|Rhoda Solin Isselbacher|June 22, 1955|November 6, 2015}} |children = 4 }} Kurt Julius Isselbacher (born September 12, 1925) is an American physician and currently the Mallinckrodt Distinguished Professor of Medicine at Harvard Medical School and Director Emeritus of the Massachusetts General Hospital Cancer Center. Early lifeIsselbacher was born in Wirges, Germany to Albert Isselbacher, a Jewish merchant and Flori Strauss, a homemaker. After suffering atrocities from the Nazis, they emigrated and took up residence in Portsmouth, New Hampshire. He currently resides in Newton, MA and was married for 60 years to Rhoda Solin Isselbacher. He has three living children, eight grandchildren, and one great-grandchild.[1] EducationAfter graduating high school in Portsmouth, Isselbacher attended Harvard College and then graduated from Harvard Medical School cum laude in 1950. After completing his residency in medicine at the Massachusetts General Hospital (MGH) in 1953, he became a clinical and research fellow at the National Institutes of Health (NIH).[2] CareerIn 1956, Isselbacher returned to MGH and Harvard and has remained there for the remainder of his professional career. He currently is the Mallinckrodt Distinguished Professor of Medicine at Harvard Medical School[3] and Director Emeritus of the Massachusetts General Hospital Cancer Center. He was elected to the National Academy of Sciences in 1973.[4] Academic and scholarly activitiesIn 1953, while still a medical resident he published work supporting the association of asbestos experience and cancer of the lung.[5] While at the NIH, he discovered the enzymatic defect causing the hereditary disorder of galactosemia.[6] This work led to the development of a test for this disorder which is now being used in routine screening of newborns. In addition, he elucidated the ennzymatic mechanism for the formation of glucuronide conjugates, important for the detoxification of many compounds by the liver.[7] After returning from the NIH in 1956, at the age of 31 he was chosen to head the Gastrointestinal Unit at the MGH.[3][8] Over the subsequent 30 years, his division became one of the leading centers of training, research and treatment of gastrointestinal diseases in the United States.[3][8] His research during this period included the description and elucidation of a new hereditary disorder of leucine metabolism called isovaleric acidemia,[9] the definition of enzymatic defects in absorptive disorders, delineations of biochemical mechanism of nutrient absorption,[10] malabsorption,[11] and protein synthesis, derangements of metabolism and immunologic aspects of hepatic gastrointestinal diseases.[3] In 1987, he undertook the challenge of becoming the first Director of the Massachusetts General Hospital Cancer Center, and in a relatively short period of time that Center emerged as a "premier" cancer research institute."[3] He became Director Emeritus in 2003. For almost 30 years, (1966-1995) he served as Chairman of the Executive Committee of Harvard's Departments of Medicine and played a pivotal role in the departments' growth and quest for excellence.[8] Dr. Isselbacher has trained over 140 clinical and research fellows both in gastroenterology and oncology and many of them have become leaders in their respective fields nationally and internationally. His publications include close to 400 journal articles and book chapters. He has served on the editorial boards of Journal of Clinical Investigation (1962-1972) and Gastorenterology (1963-1968) and was also consulting editor of Medicine (1962-1994). His leadership in medicine is also recognized nationally and internationally by virtue of his role as an editor of Harrison's Principles of Internal Medicine.[8] This book is viewed by many as the leading text in internal medicine. It is used worldwide and has been translated into 18 languages. Dr. Isselbacher has been a member and officer in many professional associations, including the National Academy of Sciences (NAS), the National Research Council, the American Academy of Arts and Sciences, and the Institute of Medicine. He served as President of American Gastroenterological Association, the American Association for Study of Liver Diseases, and the Association of American Physicians. He has also served as a member of the Science Advisory Board of the Food and Drug Administration. Dr. Isselbacher has received many awards and honors including the Distinguished Achievement Award and the Friedenwald Medal of the American Gastroenterological Association, the John Phillips Memorial Award for Distinguished Achievement in Clinical Medicine, and from Squibb/Mead Johnson the Award for Distinguished Achievement in Nutrition Research. In 2001, he received the Kober Medal of the Association of American Physicians,[12] which is the highest recognition that this Association can bestow on one of its members and also an honorary Doctor of Science degree from Northwestern University. PublicationsIsselbacher's memoir, Don't Call Me Cookie, was published in 2008 and a second edition in 2012. Personal lifeKurt Isselbacher's wife, Rhoda Solin Isselbacher, died on November 6, 2015. They had been married for 60 years. Isselbacher has three living children and one deceased child.[1] References1. ^1 {{cite web|title=Rhoda Isselbacher, 83, of Newton; lawyer, advocate for patients|url=https://www.bostonglobe.com/metro/obituaries/2015/11/10/rhoda-isselbacher-newton-lawyer-and-advocate-for-patients/ARE6sKN5PE3KlFaaNbMjFJ/story.html}} {{DEFAULTSORT:Isselbacher, Kurt Julius}}2. ^{{cite web|title=Kurt J. Isselbacher, MD - Massachusetts General Hospital, Boston, MA|url=http://www.massgeneral.org/cancer/research/isselbacher.aspx|website=MGH|accessdate=21 January 2018}} 3. ^1 2 3 4 {{cite web|url=http://www.massgeneral.org/cancerresearch/ourinvestigators/|title=Our Investigators - Massachusetts General Hospital, Boston, MA|publisher=Massgeneral.org|accessdate=November 3, 2014}} 4. ^{{cite web|url=http://www.nasonline.org/member-directory/members/54237.html|title=Kurt J. Isselbacher|publisher=National Academy of Sciences|accessdate= November 3, 2014}} 5. ^{{cite journal|last1=Isselbacher|first1=KJ|last2=Klaus|first2=H|last3=Hardy|first3=HL|date=November 1955|title=Asbestosis and Bronchogenic Carcinoma, Report of One Autopsied Case and Review of the Available Literature|journal=American Journal of Medicine|volume=40 | issue = 5 |pages=721–32}} 6. ^{{cite journal|last1=Isselbacher|first1=KJ|last2=Anderson |first2=EP|last3=Kurahashi|first3=K|last4=Kalckar|first4=HM|title=Congenital Galactosemia, a Single Enzymatic Block in Galactose Metabolism|journal=Science |pages=635–6|pmid=13311516|volume=123|date=April 1956|doi=10.1126/science.123.3198.635}} 7. ^{{cite journal |vauthors=Isselbacher KJ, Axelrod J | year = 1955 | title = Enzymatic formation of Corticosteroid Glucuronides | url = | journal = Journal of the American Chemical Society | volume = 77 | issue = | pages = 1070–1071 | doi=10.1021/ja01609a101}} 8. ^1 2 3 Braunwald E; Fauci AS; Kasper DL; Hauser SL; Longo DL; Jameson JL, eds. Harrison's Principles of Internal Medicine, 15th ed. McGraw-Hill Companies, 2001 {{ISBN|978-0-07-007272-5}};Preface xxxi. 9. ^{{cite journal |vauthors=Tanaka K, Budd MA, Efron ML, Isselbacher KJ | year = 1966 | title = Isovaleric Acidemia:A New Genetic Defect in Leucine Metabolism | url = | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 56 | issue = 1| pages = 236–242 | doi=10.1073/pnas.56.1.236 | pmid=5229850 | pmc=285701}} 10. ^PlotkinGR; Isselbacher KJ (Nov 12, 1964) Secondary Disaccharide Deficiency in Adult Celiac Disease New England Journal of Medicine 271 1033-1037 11. ^Isselbacher KJ (Jan-Feb 1965) Metabolism and Transport of Lipid by Intestinal Mucosa Federation Proceedings 24 16-22 12. ^Braunwald E (October 2001) Presentation of the Kober medal of the Association of American Physicians to Kurt J. Isselbacher, M.D. Journal of Clinical Investigation 108 (7) s15-s19 11 : 1925 births|Living people|Harvard Medical School faculty|Physicians from Massachusetts|Jewish physicians|People from Wirges|German emigrants to the United States|Members of the United States National Academy of Sciences|Harvard Medical School alumni|Harvard University alumni|American gastroenterologists |
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