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词条 Scutellaria
释义

  1. Description

  2. Traditional use

  3. Constituents and pharmacology

  4. Selected species

  5. See also

  6. References

  7. External links

{{Automatic taxobox
|image = Scutellaria pekinensis Yamatatsunamisou in Ibukiyama 2002-6-9.jpg
|image_caption = Scutellaria pekinensis
|taxon = Scutellaria
|authority = L.[1]
|synonyms =
  • Anaspis Rech.f.
  • Cruzia Phil.
  • Harlanlewisia Epling
  • Perilomia Kunth
  • Salazaria Torr.
  • Theresa Clos

| synonyms_ref =  [1]
}}Scutellaria is a genus of flowering plants in the mint family, Lamiaceae. They are known commonly as skullcaps.[2] The generic name is derived from the Latin scutella, meaning "a small dish, tray or platter",[3] or "little dish",[4] referring to the shape of the calyx.[4] The common name alludes to the resemblance of the same structure to "miniature medieval helmets".[4] The genus has a subcosmopolitan distribution,[5] with species occurring nearly worldwide, mainly in temperate regions.[6]

Description

Most are annual or perennial herbaceous plants from {{convert|5|to|100|cm|in|0|abbr=on}} tall, but a few are subshrubs; some are aquatic. They have four-angled stems and opposite leaves. The flowers have upper and lower lips. The genus is most easily recognized by the typical shield on the calyx that has also prompted its common name.

Traditional use

Skullcaps are common herbal remedies in systems of traditional medicine. In traditional Chinese medicine they are utilized to "clear away the heat-evil and expel superficial evils".[10] Scutellaria baicalensis in particular is a common component of many preparations.[7] Its root, known as Radix Scutellariae, is the source of the Chinese medicine Huang Qin. It has been in use for over 2000 years as a remedy for such conditions as hepatitis, diarrhea, and inflammation.{{citation needed|date=March 2018}} It is still in demand today, and marketed in volumes that have led to the overexploitation of the wild plant. Its rarity has led to an increase in price, and encouraged the adulteration of the product with other species of Scutellaria.[8]

In North America, Scutellaria lateriflora was used in Native American medicine to treat gynaecological conditions.{{citation needed|date=March 2018}} It became a common treatment in America for rabies.[9] Today it is still a popular medicinal herb.[10] It is widely available as a commercial product used in western herbalism to treat anxiety and muscle tension.[11] The plant reportedly commands prices of $16 to $64 per pound dry weight.[12]

Constituents and pharmacology

The main compounds responsible for the biological activity of skullcap are flavonoids.[8] Baicalein, one of the important Scutellaria flavonoids, was shown to have cardiovascular effects in in vitro.[13] Research also shows that Scutellaria root modulates inflammatory activity in vitro to inhibit nitric oxide (NO), cytokine, chemokine and growth factor production in macrophages.[14] Isolated chemical compounds including wogonin, wogonoside, and 3,5,7,2',6'-pentahydroxyl flavanone found in Scutellaria have been shown to inhibit histamine and leukotriene release.[15] Other active constituents include baicalin, apigenin, oroxylin A, scutellarein, and skullcapflavone.[16]

Some Scutellaria species, including S. baicalensis and S. lateriflora, have demonstrated anxiolytic activity in both animals and humans.[16][17][18] A variety of flavonoids in Scutellaria species have been found to bind to the benzodiazepine site and/or a non-benzodiazepine site of the GABAA receptor, including baicalin, baicalein, wogonin, apigenin, oroxylin A, scutellarein, and skullcapflavone II.[19][20][21] Baicalin and baicalein,[21][22][23][23][24] wogonin,[25] and apigenin[26] have been confirmed to act as positive allosteric modulators and produce anxiolytic effects in animals, whereas oroxylin A acts as a negative allosteric modulator (and also, notably, as a dopamine reuptake inhibitor).[27][28][29] As such, these compounds and actions, save oroxylin A, are likely to underlie the anxiolytic effects of Scutellaria species.[18]

Selected species

Estimates of the number of species in the genus range from around 300[4][6] to about 350[30][31] or 360[32] to 425.[5][33]

Species include:[2][34][35][36]

{{div col|colwidth=30em}}
  • Scutellaria alabamensis – Alabama skullcap
  • Scutellaria albida
  • Scutellaria alborosea Lem.
  • Scutellaria alpina L. – alpine skullcap
  • Scutellaria altamaha – pineland skullcap
  • Scutellaria altissima L. – Somerset skullcap, tall skullcap
  • Scutellaria amoena
  • Scutellaria anatolica[37]
  • Scutellaria angustifolia – narrowleaf skullcap
  • Scutellaria antirrhinoides Benth. – nose skullcap
  • Scutellaria arenicola – Florida scrub skullcap
  • Scutellaria arguta – Blue Ridge skullcap
  • Scutellaria atriplicifolia
  • Scutellaria aurata
  • Scutellaria baicalensis Georgi – Baikal skullcap, Chinese skullcap
  • Scutellaria barbata D.Don – barbed skullcap
  • Scutellaria bolanderi A.Gray – Sierra skullcap
  • Scutellaria brachyspica
  • Scutellaria brittonii – Britton's skullcap
  • Scutellaria bushii – Bush's skullcap
  • Scutellaria caerulea – blue skullcap
  • Scutellaria californica A.Gray – California skullcap
  • Scutellaria cardiophylla – gulf skullcap
  • Scutellaria columnae
  • Scutellaria costaricana H.Wendl. – scarlet skullcap, Costa Rican skullcap
  • Scutellaria drummondii
  • Scutellaria elliptica Muhl. – hairy skullcap
  • Scutellaria floridana Chapm. – Florida skullcap
  • Scutellaria formosana
  • Scutellaria galericulata L. – common skullcap, marsh skullcap
  • Scutellaria glabriuscula – Georgia skullcap
  • Scutellaria hastifolia – spear-leaved skullcap
  • Scutellaria havanensis – Havana skullcap
  • Scutellaria hirta
  • Scutellaria hookeri
  • Scutellaria humilis
  • Scutellaria incana Biehler – downy skullcap, hoary skullcap
  • Scutellaria incarnata Vent.
  • Scutellaria indica L.
  • Scutellaria integrifolia L. – helmet flower
  • Scutellaria laevis – Culberson County skullcap
  • Scutellaria lateriflora L. – blue skullcap, Virginian skullcap
  • Scutellaria longifolia Benth.
  • Scutellaria longituba
  • Scutellaria meehanioides
  • Scutellaria microphylla – littleleaf skullcap
  • Scutellaria minor Huds. – lesser skullcap
  • Scutellaria montana Chapm. – mountain skullcap, large-flowered skullcap
  • Scutellaria multiglandulosa – Small's skullcap
  • Scutellaria muriculata – Rio Grande skullcap
  • Scutellaria nana A.Gray – dwarf skullcap
  • Scutellaria nervosa – veiny skullcap
  • Scutellaria novae-zelandaie
  • Scutellaria ocmulgee – Ocmulgee skullcap
  • Scutellaria orientalis
  • Scutellaria ovata Hill – heart-leaved skullcap
  • Scutellaria parvula Michx. – small skullcap
  • Scutellaria pekinensis
  • Scutellaria potosina – Mexican skullcap
  • Scutellaria pseudoserrata – falseteeth skullcap
  • Scutellaria purpurascens
  • Scutellaria racemosa – South American skullcap
  • Scutellaria rehderiana
  • Scutellaria resinosa Torr. – sticky skullcap
  • Scutellaria rubicunda
  • Scutellaria sapphirina – White Pine skullcap
  • Scutellaria saxatilis – smooth rock skullcap
  • Scutellaria serboana[38]
  • Scutellaria serrata – showy skullcap
  • Scutellaria siphocampyloides – grayleaf skullcap
  • Scutellaria splendens
  • Scutellaria strigillosa
  • Scutellaria suffrutescens
  • Scutellaria texana – Texas skullcap
  • Scutellaria thieretii – Thieret's skullcap
  • Scutellaria tuberosa Benth. – Danny's skullcap
  • Scutellaria utriculata – Endemic to Lebanon and Northern Israel
  • Scutellaria ventenatii
  • Scutellaria violacea
  • Scutellaria viscidula
  • Scutellaria wrightii – Wright's skullcap
{{div col end}}

See also

  • Piper methysticum (kava), another anxiolytic GABAergic plant
  • Valeriana officinalis (valerian), a sedative GABAergic plant
  • Chaenomeles speciosa, also contains a constituent that acts as a dopamine reuptake inhibitor

References

1. ^1 {{cite web |url=http://www.ars-grin.gov/cgi-bin/npgs/html/genus.pl?11003 |title=Genus: Scutellaria L. |work=Germplasm Resources Information Network |publisher=United States Department of Agriculture |date=2006-11-03 |accessdate=2010-11-12}}
2. ^1 {{ITIS |id=32764 |taxon=Scutellaria |accessdate=2010-11-12}}
3. ^Scutellaria parvula var. missouriensis. Robert W. Freckmann Herbarium. University of Wisconsin, Stevens Point.
4. ^1 2 3 {{cite book |first1=Nirmal |last1=Joshee |first2=Thomas S. |last2=Patrick |first3=Rao S. |last3=Mentreddy |first4=Anand K |last4=Yadav |year=2002 |chapter-url=http://www.hort.purdue.edu/newcrop/ncnu02/v5-580.html |chapter=Skullcap: Potential medicinal crop |pages=580–6 |editor1-last=Janick |editor1-first=J. |editor2-first=A. |editor2-last=Whipkey |title=Trends in New Crops and New Uses |location=Alexandria, Virginia |publisher=ASHS Press}}
5. ^1 Ulloa, C. U. and P. M. Jørgensen. Scutellaria. Árboles y arbustos de los Andes del Ecuador. eFloras.
6. ^1 Scutellaria. The Jepson eFlora 2013.
7. ^{{cite journal |last1=Cole |first1=Ian |last2=Cao |first2=Jin |last3=Alan |first3=Ali |last4=Saxena |first4=Praveen |last5=Murch |first5=Susan |year=2008 |title=Comparisons of Scutellaria baicalensis, Scutellaria lateriflora and Scutellaria racemosa: Genome Size, Antioxidant Potential and Phytochemistry |journal=Planta Medica |volume=74 |issue=4 |pages=474–81 |pmid=18484546 |doi=10.1055/s-2008-1034358}}
8. ^1 {{cite journal |last1=Guo |first1=Xiaorong |last2=Wang |first2=Xiaoguo |last3=Su |first3=Wenhua |last4=Zhang |first4=Guangfei |last5=Zhou |first5=Rui |year=2011 |title=DNA Barcodes for Discriminating the Medicinal Plant Scutellaria baicalensis (Lamiaceae) and Its Adulterants |journal=Biological & Pharmaceutical Bulletin |volume=34 |issue=8 |pages=1198–203 |pmid=21804206 |doi=10.1248/bpb.34.1198}}
9. ^Scutellaria lateriflora. Southern Cross Plant Science. Southern Cross University.
10. ^{{cite journal |last1=Li |first1=Jing |last2=Wang |first2=Yan-Hong |last3=Smillie |first3=Troy J. |last4=Khan |first4=Ikhlas A. |year=2012 |title=Identification of phenolic compounds from Scutellaria lateriflora by liquid chromatography with ultraviolet photodiode array and electrospray ionization tandem mass spectrometry |journal=Journal of Pharmaceutical and Biomedical Analysis |volume=63 |pages=120–7 |pmid=22342658 |doi=10.1016/j.jpba.2012.01.027}}
11. ^{{cite journal |first1=Jiayu |last1=Gao |first2=Alberto |last2=Sanchez-Medina |first3=Barbara A. |last3=Pendry |first4=Michael J. |last4=Hughes |first5=Geoffrey P. |last5=Webb |first6=Olivia |last6=Corcoran |year=2008 |title=Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures |journal=Journal of Pharmacy & Pharmaceutical Sciences |volume=11 |issue=1 |pages=77–87 |pmid=18445366 |url=http://ejournals.library.ualberta.ca/index.php/JPPS/article/view/1122/1150|doi=10.18433/J39G6V }}
12. ^Janke, R. A Grower's Guide: Scullcap (Scutellaria lateriflora). MF-2628. Cooperative Extension, Kansas State University. 2004.
13. ^{{cite journal |last1=Huang |first1=Yu |last2=Tsang |first2=Suk-Ying |last3=Yao |first3=Xiaoqiang |last4=Chen|first4=Zhen-Yu |year=2005 |title=Biological Properties of Baicalein in Cardiovascular System |journal=Current Drug Targets |volume=5 |issue=2 |pages=177–84 |pmid=15853750 |doi=10.2174/1568006043586206}}
14. ^{{cite journal |last1=Kim |first1=Eun Hye |last2=Shim |first2=Bumsang |last3=Kang |first3=Seunghee |last4=Jeong |first4=Gajin |last5=Lee |first5=Jong-soo |last6=Yu |first6=Young-Beob |last7=Chun |first7=Mison |year=2009 |title=Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules |journal=Journal of Ethnopharmacology |volume=126 |issue=2 |pages=320–31 |pmid=19699788 |doi=10.1016/j.jep.2009.08.027}}
15. ^{{cite journal |last1=Lim |first1=Beong Ou |year=2003 |title=Effects of wogonin, wogonoside, and 3,5,7,2′,6′-pentahydroxyflavone on chemical mediator production in peritoneal exduate cells and immunoglobulin E of rat mesenteric lymph node lymphocytes |journal=Journal of Ethnopharmacology |volume=84 |issue=1 |pages=23–9 |pmid=12499072 |doi=10.1016/S0378-8741(02)00257-X}}
16. ^1 {{cite journal | vauthors = Awad R, Arnason JT, Trudeau V, Bergeron C, Budzinski JW, Foster BC, Merali Z | title = Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties | journal = Phytomedicine | volume = 10 | issue = 8 | pages = 640–9 | year = 2003 | pmid = 14692724 | doi = 10.1078/0944-7113-00374 | url = http://linkinghub.elsevier.com/retrieve/pii/S0944-7113(04)70276-7}}
17. ^{{cite journal | vauthors = Wolfson P, Hoffmann DL | title = An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers | journal = Altern Ther Health Med | volume = 9 | issue = 2 | pages = 74–8 | year = 2003 | pmid = 12652886 | doi = | url = }}
18. ^1 {{cite book|author=Stefanie Schwartz|title=Psychoactive Herbs in Veterinary Behavior Medicine|url=https://books.google.com/books?id=ZP6QVep-x24C&pg=PA139|date=9 January 2008|publisher=John Wiley & Sons|isbn=978-0-470-34434-7|pages=139–}}
19. ^{{cite journal | vauthors = Wang H, Hui KM, Chen Y, Xu S, Wong JT, Xue H | title = Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex | journal = Planta Med. | volume = 68 | issue = 12 | pages = 1059–62 | year = 2002 | pmid = 12494329 | doi = 10.1055/s-2002-36357 }}
20. ^{{cite journal | vauthors = Hui KM, Wang XH, Xue H | title = Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site | journal = Planta Med. | volume = 66 | issue = 1 | pages = 91–3 | year = 2000 | pmid = 10705749 | doi = 10.1055/s-0029-1243121 }}
21. ^1 {{cite journal | vauthors = Liao JF, Wang HH, Chen MC, Chen CC, Chen CF | title = Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root | journal = Planta Med. | volume = 64 | issue = 6 | pages = 571–2 | year = 1998 | pmid = 9776664 | doi = 10.1055/s-2006-957517 }}
22. ^{{cite book|author1=Edwin Lowell Cooper|author2=Nobuo Yamaguchi|title=Complementary and Alternative Approaches to Biomedicine|url=https://books.google.com/books?id=rCMYNGmOKygC&pg=PA188|date=1 January 2004|publisher=Springer Science & Business Media|isbn=978-0-306-48288-5|pages=188–}}
23. ^1 {{cite journal | vauthors = Wang F, Xu Z, Ren L, Tsang SY, Xue H | title = GABA A receptor subtype selectivity underlying selective anxiolytic effect of baicalin | journal = Neuropharmacology | volume = 55 | issue = 7 | pages = 1231–7 | year = 2008 | pmid = 18723037 | doi = 10.1016/j.neuropharm.2008.07.040 | url = http://linkinghub.elsevier.com/retrieve/pii/S0028-3908(08)00325-0}}
24. ^{{cite journal | vauthors = Liao JF, Hung WY, Chen CF | title = Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice | journal = Eur. J. Pharmacol. | volume = 464 | issue = 2–3 | pages = 141–6 | year = 2003 | pmid = 12620506 | doi = 10.1016/s0014-2999(03)01422-5}}
25. ^{{cite journal | vauthors = Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, Baur R, Ren H, Li ZW, Wong JT, Xue H | title = Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi | journal = Biochem. Pharmacol. | volume = 64 | issue = 9 | pages = 1415–24 | year = 2002 | pmid = 12392823 | doi = 10.1016/s0006-2952(02)01347-3}}
26. ^{{cite journal | vauthors = Viola H, Wasowski C, Levi de Stein M, Wolfman C, Silveira R, Dajas F, Medina JH, Paladini AC | title = Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects | journal = Planta Med. | volume = 61 | issue = 3 | pages = 213–6 | year = 1995 | pmid = 7617761 | doi = 10.1055/s-2006-958058 }}
27. ^{{cite journal | vauthors = Huen MS, Leung JW, Ng W, Lui WS, Chan MN, Wong JT, Xue H | title = 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties | journal = Biochem. Pharmacol. | volume = 66 | issue = 1 | pages = 125–32 | year = 2003 | pmid = 12818372 | doi = 10.1016/s0006-2952(03)00233-8}}
28. ^{{cite journal | vauthors = Liu X, Hong SI, Park SJ, Dela Peña JB, Che H, Yoon SY, Kim DH, Kim JM, Cai M, Risbrough V, Geyer MA, Shin CY, Cheong JH, Park H, Lew JH, Ryu JH | title = The ameliorating effects of 5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one, an oroxylin A derivative, against memory impairment and sensorimotor gating deficit in mice | journal = Arch. Pharm. Res. | volume = 36 | issue = 7 | pages = 854–63 | year = 2013 | pmid = 23543630 | doi = 10.1007/s12272-013-0106-6 }}
29. ^{{cite journal|last1=Yoon|first1=Seo Young|last2=dela Peña|first2=Ike|last3=Kim|first3=Sung Mok|last4=Woo|first4=Tae Sun|last5=Shin|first5=Chan Young|last6=Son|first6=Kun Ho|last7=Park|first7=Haeil|last8=Lee|first8=Yong Soo|last9=Ryu|first9=Jong Hoon|last10=Jin|first10=Mingli|last11=Kim|first11=Kyeong-Man|last12=Cheong|first12=Jae Hoon|title=Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro|journal=Archives of Pharmacal Research|volume=36|issue=1|year=2013|pages=134–140|issn=0253-6269|doi=10.1007/s12272-013-0009-6|pmid=23371806}}
30. ^1 {{cite journal |last1=Shang |first1=Xiaofei |last2=He |first2=Xirui |last3=He |first3=Xiaoying |last4=Li |first4=Maoxing |last5=Zhang |first5=Ruxue |last6=Fan |first6=Pengcheng |last7=Zhang |first7=Quanlong |last8=Jia |first8=Zhengping |year=2010 |title=The genus Scutellaria an ethnopharmacological and phytochemical review |journal=Journal of Ethnopharmacology |volume=128 |issue=2 |pages=279–313 |pmid=20064593 |doi=10.1016/j.jep.2010.01.006}}
31. ^Scutellaria. Flora of China.
32. ^{{cite journal |last1=Pool |first1=Amy |year=2006 |title=New Species of Scutellaria (Lamiaceae) from Mesoamerica |journal=Novon |volume=16 |issue=3 |pages=388–403 |jstor=20406083 |doi=10.3417/1055-3177(2006)16[388:NSOSLF]2.0.CO;2}}
33. ^{{cite journal |last1=Hsu |first1=Tsai-Wen |last2=Kuo |first2=Chia-Chi |last3=Tsai |first3=Chi-Chu |last4=Chiang |first4=Yu-Chung |year=2009 |title=Isolation and characterization of 16 microsatellite markers from a rare and endemic species, Scutellaria austrotaiwanensis (Lamiaceae) |journal=Conservation Genetics Resources |volume=1 |issue=1 |pages=85–8 |doi=10.1007/s12686-009-9020-0}}
34. ^Scutellaria, list of taxa. Flora of China.
35. ^{{cite web |url=http://www.ars-grin.gov/cgi-bin/npgs/html/splist.pl?11003 |title=GRIN Species Records of Scutellaria |work=Germplasm Resources Information Network |publisher=United States Department of Agriculture |accessdate=2010-11-12}}
36. ^Scutellaria, list of taxa. Flora of Pakistan.
37. ^{{cite journal |last1=Çiçek |first1=Mehmet |last2=Ketenoğlu |first2=Osman |year=2011 |title=Scutellaria anatolica (Lamiaceae), a New Species from Turkey |journal=Annales Botanici Fennici |volume=48 |issue=3 |pages=276–9 |doi=10.5735/085.048.0309}}
38. ^{{cite journal |first1=Billie L. |last1=Turner |year=2011 |url=http://www.phytologia.org/uploads/2/3/4/2/23422706/932241-244turnerscutellaria.pdf |title=A new species of Scutellaria (Lamiaceae) from Oaxaca, Mexico |journal=Phytologia |volume=93 |issue=2 |pages=241–4}}

External links

  • {{Commons category-inline|Scutellaria|Scutellaria}}
  • {{Wikispecies-inline|Scutellaria|Scutellaria}}
  • {{cite web |url=http://plants.usda.gov/java/profile?symbol=SCUTE |title=Scutellaria L. (skullcap) |work=The PLANTS Database |publisher=United States Department of Agriculture}}
  • Scutellaria images. MorphBank.
{{Anxiolytics}}{{GABAAR PAMs}}{{Taxonbar|from=Q156764}}

7 : Scutellaria|Lamiaceae genera|Medicinal plants|Anxiolytics|Dopamine reuptake inhibitors|GABAA receptor positive allosteric modulators|Taxa named by Carl Linnaeus
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