| 词条 | L-165041 |
| 释义 |
| verifiedrevid = | IUPAC_name = [4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid[1] | image = L-165041 skeletal.svg | width = | tradename = | MedlinePlus = | pregnancy_category = N/A | legal_status = Investigational | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | IUPHAR_ligand = 2691 | CAS_number = 79558-09-1 | ATC_prefix = | ATC_suffix = | PubChem = 6603901 | DrugBank = DB08078 | ChemSpiderID = 5036209 | C=22 | H=26 | O=7 | molecular_weight = 402.438 g/mol | smiles = CCCc1c(ccc(c1O)C(=O)C)OCCCOc2ccc(cc2)OCC(=O)O | StdInChI = 1S/C22H26O7/c1-3-5-19-20(11-10-18(15(2)23)22(19)26)28-13-4-12-27-16-6-8-17(9-7-16)29-14-21(24)25/h6-11,26H,3-5,12-14H2,1-2H3,(H,24,25) | StdInChIKey = HBBVCKCCQCQCTJ-UHFFFAOYSA-N }}L-165041 is a phenyloxyacetate PPARδ receptor agonist. It is less potent and PPARδ selective than GW 501516.[2] See also
References1. ^{{Cite journal | last1 = Iwashita | first1 = A. | last2 = Muramatsu | first2 = Y. | last3 = Yamazaki | first3 = T. | last4 = Muramoto | first4 = M. | last5 = Kita | first5 = Y. | last6 = Yamazaki | first6 = S. | last7 = Mihara | first7 = K. | last8 = Moriguchi | first8 = A. | last9 = Matsuoka | first9 = N. | doi = 10.1124/jpet.106.115758 | title = Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor -Selective Agonists in Vitro and in Vivo | journal = Journal of Pharmacology and Experimental Therapeutics | volume = 320 | issue = 3 | pages = 1087–1096 | year = 2006 | pmid = 17167170 | pmc = }} {{pharma-stub}}2. ^{{cite book|author=Atta-ur- Rahman, Allen B. Reitz|title=Frontiers in Medicinal Chemistry, Volume 2|url=https://books.google.com/books?id=tCyDoIHToBQC&pg=PA244&lpg=PA244|accessdate=2 April 2013|year=2005|publisher=Bentham Science Publishers|isbn=978-1-608-05205-9|pages=244–}} 1 : PPAR agonists |
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