| 词条 | LCCL domain |
| 释义 |
| Symbol = LCCL | Name = LCCL | image = | width = | caption = | Pfam = PF03815 | Pfam_clan = CL0513 | InterPro = IPR004043 | SMART = | PROSITE = | MEROPS = | SCOP = 1jbi | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, the LCCL domain is a protein domain which has been named after several well-characterised proteins that were found to contain it, namely Limulus clotting factor C, Coch-5b2 (Cochlin) and Lgl1. It is an about 100 amino acids domain whose C-terminal part contains a highly conserved histidine in a conserved motif YxxxSxxCxAAVHxGVI. The LCCL module is thought to be an autonomously folding domain that has been used for the construction of various modular proteins through exon-shuffling. It has been found in various metazoan proteins in association with complement B-type domains, C-type lectin domains, von Willebrand type A domains, CUB domains, discoidin lectin domains or CAP domains. It has been proposed that the LCCL domain could be involved in lipopolysaccharide (LPS) binding.[1][2] Secondary structure prediction suggests that the LCCL domain contains six beta strands and two alpha helices.[1] Some proteins known to contain a LCCL domain include Limulus factor C, an LPS endotoxin-sensitive trypsin type serine protease which serves to protect the organism from bacterial infection; vertebrate cochlear protein cochlin or coch-5b2 (Cochlin is probably a secreted protein, mutations affecting the LCCL domain of coch-5b2 cause the deafness disorder DFNA9 in humans); and mammalian late gestation lung protein Lgl1, contains two tandem copies of the LCCL domain.[3] References1. ^1 {{cite journal |vauthors=Trexler M, Banyai L, Patthy L | title = The LCCL module | journal = Eur. J. Biochem. | volume = 267 | issue = 18 | pages = 5751–7 |date=September 2000 | pmid = 10971586 | doi = 10.1046/j.1432-1327.2000.01641.x| url = }} {{InterPro content|IPR004043}}2. ^{{cite journal |vauthors=Robertson NG, Lu L, Heller S, Merchant SN, Eavey RD, McKenna M, Nadol JB, Miyamoto RT, Linthicum FH, Lubianca Neto JF, Hudspeth AJ, Seidman CE, Morton CC, Seidman JG | title = Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction | journal = Nat. Genet. | volume = 20 | issue = 3 | pages = 299–303 |date=November 1998 | pmid = 9806553 | doi = 10.1038/3118 | url = }} 3. ^{{cite journal |vauthors=Kaplan F, Ledoux P, Kassamali FQ, Gagnon S, Post M, Koehler D, Deimling J, Sweezey NB | title = A novel developmentally regulated gene in lung mesenchyme: homology to a tumor-derived trypsin inhibitor | journal = Am. J. Physiol. | volume = 276 | issue = 6 Pt 1 | pages = L1027-36 |date=June 1999 | pmid = 10362728 | doi = | url = }} 1 : Protein domains |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。