The American actress Lea Thompson has performed in many well-known films and television series since the 1980s, among them the Back to the Future trilogy and Caroline in the City.
| Year | Title | Role | Notes |
|---|
| 1982 | MysteryDisc: Murder, Anyone? | Cecily 'Sissy' Loper | Video/debut |
| 1983 | Jaws 3-D | Kelly Ann Bukowski |
| All the Right Moves | Lisa Lietzke |
| 1984 | Red Dawn | Erica Mason |
| {{sortname>The| Wild Life| The Wild Life (film)}} | Anita |
| 1985 | Back to the Future | Lorraine Baines McFly |
| 1986 | SpaceCamp | Kathryn Fairly |
| Howard the Duck | Beverly Switzler |
| 1987 | Some Kind of Wonderful | Amanda Jones |
| 1988 | Casual Sex? | Stacy |
| Yellow Pages | Marigold de la Hunt | AKA Going Undercover |
| {{sortname>The| Wizard of Loneliness| The Wizard of Loneliness (film)}} | Sybil |
| 1989 | Back to the Future Part II | Lorraine McFly |
| 1990 | Back to the Future Part III | Maggie/Lorraine McFly |
| 1992 | Article 99 | Dr. Robin Van Dorn |
| 1993 | Stolen Babies | Annie Beales |
| Dennis the Menace | Mrs. Alice Mitchell |
| {{sortname>The| Beverly Hillbillies| The Beverly Hillbillies (film)}} | Laura Jackson |
| 1994 | {{sortname>The| Little Rascals| The Little Rascals (film)}} | Ms. Roberts |
| 1998 | {{sortname>The| Unknown Cyclist| nolink=1}} | Melissa Cavatelli | AKA 4 for the Road |
| 2002 | Fish Don't Blink | Clara |
| 2003 | Haunted Lighthouse | Peg Van Legge | Short film |
| 2005 | Come Away Home | Carol |
| 2006 | 10 Tricks | Grace |
| 2007 | California Dreaming | Ginger Gainor | AKA Out of Omaha |
| 2008 | Spy School | Claire Miller | AKA Doubting Thomas |
| Senior Skip Day | Cathleen Harris | Video, DVD title: High School's Day Off |
| Exit Speed | Maudie McMinn |
| 2009 | Fatal Secrets | Rebecca | AKA Balancing the Books, also associate producer |
| {{sortname>The| Check| nolink=1}} | Darla | Short film, ACME Comedy |
| Rock Slyde | Master Bartologist | DVD title: Rock Slyde: Private Eye |
| Splinterheads | Susan Frost |
| 2010 | Adventures of a Teenage Dragon Slayer | Laura | AKA I Was a 7th Grade Dragon Slayer |
| Pork Chop Night | — | Short, associate producer |
| 2011 | Thin Ice | Jo Ann Prohaska | AKA The Convincer |
| Mayor Cupcake | Mary Maroni | Also executive producer |
| The Trouble with the Truth | Emily | Also producer |
| J. Edgar | Lela Rogers |
| 2014 | Ping Pong Summer | Crandall Miracle |
| Left Behind | Irene Steele |
| 2015 | The Wrong Side of Right | Liz |
| 2017 | Literally, Right Before Aaron | Deb |
| The Year Of Spectacular Men | Deb Klein |
| 2018 | Sierra Burgess Is a Loser | Mrs. Burgess |
| Little Women | Marmee March |
| Year | Title | Role | Notes |
|---|
| 1989 | Nightbreaker | Sally Matthews | AKA Advance to Ground Zero, TV film |
| Tales from the Crypt | Sylvia Vane | Episode: "Only Sin Deep" |
| 1990 | Montana | Peg Guthrie | TV film |
| 1993 | Stolen Babies | Annie Beales | AKA Stolen Children, TV film |
| 1994 | {{sortname>The|Substitute Wife|link=The Substitute Wife (1994 film)}} | Amy Hightower | AKA The Substitute, TV film |
| 1995 | {{sortname>The|Unspoken Truth|nolink=1}} | Brianne Hawkins | AKA Living the Lie, TV film |
| Friends | Caroline Duffy | Episode: "The One with the Baby on the Bus", uncredited |
| 1995–99 | Caroline in the City | Caroline Duffy | 97 episodes, also producer on 22 episodes |
| 1996 | {{sortname>The|Right to Remain Silent|link=The Right to Remain Silent}} | Christine Paley | TV film |
| 1998 | {{sortname>A|Will of their Own|link=A Will of their Own}} | Amanda Steward | AKA Daughters of the New World, pilot episode |
| 2002 | Electric | Geri Meyers | Also producer |
| 2002–03 | For the People | Chief Dep. Dist. Atty. Camille Paris | 18 episodes |
| 2003 | Stealing Christmas | Sarah Gibson | TV film |
| 2004 | Ed | Liz Stevens | 3 episodes |
| Special Victims Unit | Michelle Osborne | Episode: "Birthright" |
| 2005 | Vanishing Act | Cathy Davis | Jane Doe TV anthology |
| Jane Doe: Now You See It, Now You Don't | Cathy Davis | Jane Doe TV anthology |
| Jane Doe: Til Death Do Us Part | Cathy Davis | Jane Doe TV anthology |
| Jane Doe: The Wrong Face | Cathy Davis | Jane Doe TV anthology |
| 2006 | Jane Doe: Yes, I Remember It Well | Cathy Davis | Jane Doe TV anthology |
| Jane Doe: The Harder They Fall | Cathy Davis | Jane Doe TV anthology, also director |
| 2007 | Jane Doe: Ties That Bind | Cathy Davis/Jane Doe | AKA Jane Doe: Shaken & Stirred, Jane Doe TV anthology |
| {{sortname>A|Life Interrupted}} | Debbie Smith | AKA The Debbie Smith Story, TV film |
| Jane Doe: How to Fire Your Boss | Cathy Davis | Jane Doe TV anthology, video |
| Final Approach | Alicia Bender | AKA Highjack, TV film |
| 2008 | Jane Doe: Eye of the Beholder | Cathy Davis/Jane Doe | Also director |
| Head Case | Herself | Also writer on episode: "El Finks" |
| {{sortname>The|Christmas Clause|nolink=1}} | Sophie | AKA The Mrs. Clause, TV film |
| 2010 | Greek | April | Episode: "Camp Buy Me Love" |
| Uncle Nigel | Abby Wells | TV film |
| 2011 | Robot Chicken | Lorraine Baines | Episode: "Major League of Extraordinary Gentlemen", voice |
| {{sortname>The|Cabin|}} | Lily MacDougall | TV film |
| Game of Your Life | Abbie | TV film |
| 2011–2017 | Switched at Birth | Kathryn Kennish | 73 episodes, also director on 2 episodes |
| 2012 | Love at the Christmas Table | Elissa Beth Dixon | AKA It's a Wonderful Lifetime, TV film |
| 2013 | A Five Film | Julia | Television film, segment: "Eddie" |
| Family Guy | Lorraine McFly | Voice, episode: "Finders Keepers" |
| CSI: Crime Scene Investigation | Jennifer Rhodes | Episode: "Under a Cloud" |
| 2014 | My Mother's Future Husband | René Henderson |
| 2014–2017 | Part-Time Hero | Vonnie Zero | Voice, recurring role |
| 2014 | A to Z | Herself | Episode: "'A' is for Acquaintances" |
| 2015 | The Muppets | Herself | Episode: 2 |
| 2016 | Whose Line is it Anyway? | Herself | Episode: 15 |
| ‘’American Dad!’’ | Caroline Duffy | Voice, Episode: 217 |
| 2016-17 | Scorpion | Veronica Dineen | 4 episodes |