| 词条 | Leloir pathway |
| 释义 |
The Leloir pathway is a metabolic pathway for the catabolism of D-galactose. It is named after Luis Federico Leloir. In the first step, galactose mutarotase facilitates the conversion of β-D-galactose to α-D-galactose since this is the active form in the pathway. Next, α-D-galactose is phosphorylated by galactokinase to galactose 1-phosphate. In the third step, D-galactose-1-phosphate uridylyltransferase converts galactose 1-phosphate to UDP-galactose using UDP-glucose as the uridine diphosphate source. Finally, UDP-galactose 4-epimerase recycles the UDP-galactose to UDP-glucose for the transferase reaction. Additionally, phosphoglucomutase converts the D-glucose 1-phosphate to D-glucose 6-phosphate.[2][3] References1. ^1 {{cite journal |author=Frey PA |title=The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose |journal=FASEB J. |volume=10 |issue=4 |pages=461–70 |date=March 1996 |pmid=8647345 |doi= |url=http://www.fasebj.org/cgi/pmidlookup?view=long&pmid=8647345 |accessdate=2011-04-01}} 2. ^1 {{citation | last1=Garrett | first1=Reginald | year=2010 | title=Biochemistry | last2=Grisham | first2=Charles M. | edition=4 | publisher=Cengage Learning | isbn=978-0-495-10935-8 | page=556 | url=https://books.google.com/books?id=iGPsen3fSOIC&pg=PA556&ved=0CC0Q6AEwAA#v=onepage&q&f=false }}
}}{{portal bar|Metabolism}} 2 : Metabolism|Galactose |
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