| 词条 | Liang Tong |
| 释义 |
| name = Liang Tong | image = | image_size = | alt = | caption = | birth_date = | birth_place = | death_date = | death_place = | residence = | citizenship = United States of America | nationality = American | fields = Biology | workplaces = Columbia University | alma_mater = Peking University BS in Chemistry (1983), University of California, Berkeley PhD (1989) | doctoral_advisor = Kim Sung-Hou | academic_advisors = | doctoral_students = | notable_students = | known_for = | author_abbrev_bot = | author_abbrev_zoo = | influences = | influenced = | awards = | signature = | signature_alt = | footnotes = | spouse = | website = http://tonglab.biology.columbia.edu/ }} Liang Tong is the current chair of the Biological Sciences Department at Columbia University.[1] His lab focuses on enzymes involved in fatty acid metabolism, including Acetyl-CoA carboxylase, carnitine acyltransferase, AMP-activated protein kinase, and others. These enzymes are important targets for drug discovery against obesity, diabetes and other human diseases. The goal of his research is to produce structural information on these enzymes and to understand their functions at the molecular level. The structural information will also lay the foundation for drug discovery against these targets. Another area of his research is on proteins involved in pre-mRNA 3'-end processing. Most eukaryotic mRNA precursors must undergo cleavage and polyadenylation in their 3'-ends before they can function as mRNAs. This processing machinery contains more than 16 protein factors, which form several sub-complexes (CPSF, CSTF). The goal of his research is to understand the molecular basis of this important event. Recent Academic Papers
References1. ^{{cite web|url=http://tonglab.biology.columbia.edu/People/cv_Tong.pdf|title=Liang Tong Brief CV}} {{authority control}}{{DEFAULTSORT:Tong, Liang}} 4 : 21st-century American biologists|Living people|Columbia University faculty|Year of birth missing (living people) |
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