Lifeblood or Life blood can refer to:

• Blood, a bodily fluid in animals
• Life Blood (film), a supernatural horror thriller film released in 2009
• Lifeblood (album), the seventh studio album by the Welsh alternative rock band Manic Street Preachers
• Lifeblood (novel), sequel to the novel Darkside, a children's novel by Tom Becker
• Life's Blood, an American hardcore punk band
• "Life's Blood" (song), a song by the American metalcore band Eighteen Visions
• Lifeblood, the Thrombosis Charity, a UK-based charity aiming to increase awareness of thrombosis among the public and health professionals

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