The following numbered county roads exist in DeSoto County, Florida. As with most Florida counties, numbers are assigned in a statewide grid.
{{-}}| # | Name | From | To | Notes | | CR 35A}}{{jct|state=FL|CR|35A|county1=DeSoto}} | SW Senate Street / SW Hull Avenue | US 17 (SR 35) in Fort Ogden | US 17 (SR 35) east-northeast of Hull | Former SR 35A[1] |
| CR 660}}{{jct|state=FL|CR|660|county1=DeSoto}} | US 17 (SR 35) / SE McKay Street in Cubitis | NE Cubitis Avenue north-northeast of Cubitis | Former SR 660;[2] FDOT's DeSoto County map indicates that CR 660's northern terminus is at a second intersection with US 17 (SR 35), but road signs on US 17 (SR 35) indicate that it continues to NE Cubitis Avenue. |
| CR 661}}{{jct|state=FL|CR|661|county1=DeSoto}} | CR 760 / SW Stroble Avenue west-northwest of Nocatee
SR 70 northwest of Arcadia | SR 72 west of Arcadia
CR 661 / NW Kinsey County Line Road at the Hardee County line north of Arcadia | Former SR 661[2] |
| CR 661A}}{{jct|state=FL|CR|661A|county1=DeSoto}} | SR 70 west of Arcadia | NW Coker Street northwest of Arcadia | Former SR 661A[2] |
| CR 760}}{{jct|state=FL|CR|760|county1=DeSoto}} | CR 769 west-northwest of Nocatee
SR 31 southeast of Southeast Arcadia | US 17 (SR 35) / SW Welles Avenue in Nocatee
SR 70 east of Arcadia | Former SR 760[2] |
| CR 760A}}{{jct|state=FL|CR|760A|county1=DeSoto}} | US 17 / SW McCaskill Street southwest of Nocatee | SR 31 east of Nocatee | Former SR 760A[2] |
| CR 761}}{{jct|state=FL|CR|761|county1=DeSoto}} | US 17 / SW Madison Avenue east of Southfort | CR 769 in Platt | Former SR 761[2] |
| CR 763}}{{jct|state=FL|CR|763|county1=DeSoto}} | SE North Hog Bay Extension | SR 31 southeast of Southeast Arcadia | SR 31 / East Farms Road south-southeast of Nocatee | Former SR 763[2] |
| CR 769}}{{jct|state=FL|CR|769|county1=DeSoto}} | CR 769 / SW Courtly Manor Drive at the Charlotte County line south of Lake Suzy | SR 72 west-southwest of Arcadia | Former SR 741 (south of CR 761)[3] and SR 761 (north of CR 761)[2] |
1. ^FDOT right of way map, section 04581-2601
2. ^1 2 3 4 5 6 7 {{cite web |url=http://ufdc.ufl.edu/UF00016192/00001/1x?vo=32 |title=General Highway Map – De Soto County |date=January 1971 |publisher= }}
3. ^FDOT right of way map, section 04504-2601