| 词条 | Pervasive refusal syndrome |
| 释义 |
| name = Pervasive refusal syndrome | synonyms = Pervasive arousal withdrawal syndrome | image = | alt = | caption = | pronounce = | field = Psychiatry | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} Pervasive refusal syndrome (PRS), also known as pervasive arousal withdrawal syndrome (PAWS), is a mental disorder in children. Children with the disorder abandon their involvement in all phases of their life. It is characterized by refusal to eat, drink, talk, walk or self-care, and a firm resistance to treatment. PRS starts slowly, but the child then worsens quickly becoming reluctant or not capable to do anything for themselves. They are very depressed and distraught. Its cause is unclear. The disorder usually begins with a 'virus', or the child having a 'pain', even though no substantial cause can be found. A family with a psychiatric history or environmental stress factors can also play a role. It is not included in the standard psychiatric classification systems. Hospitalization is almost always necessary and the recovery period is typically more than a year. During the recovery period symptoms disappear in the opposite order they appear.[1] About 67% of the cases show complete recovery.[2] Nevertheless, once the person is healthy, relapse is very infrequent. PRS is rare. It was first described by Bryan Lask and colleagues in 1991.[3] Signs and symptomsPRS symptoms have common characteristics with many other psychiatric disorders. However, none of the present DSM diagnoses can account for the full scope of symptoms seen in PRS, and refusal to eat, weight loss, social withdrawal and school refusal can be considered as the main distinctive features.[2] Any system may be involved, however some more commonly engaged than others.[4] Gastrointestinal:[4]
ComorbidityAutismAutism is a neural development disorder defined by flawed social interaction and communication, and by restricted and repetitive behavior.[5] The patient with autism displays substantial deficit in all three core deficits of PRS which include: impairments in social interaction, impairments in communication, and restricted and stereotyped patterns of behavior, interests, and activities.[5]Asperger's syndromeAsperger's syndrome (AS) is characterized by considerable problems in social interaction, other notable symptoms include restricted and repetitive patterns of behavior and activities.[5] Patient with AS generally has no setback in language cognitive maturity, or self-help abilities but has clear language skill deficits, problems in social interaction, and odd behavior in interests and activities characteristic of PRS.[5] The lack of cognitive development deficits enables the patient with AS to perform at a more advanced level than people who have other forms of PRS.[5]CauseTrauma, in general, appears to be an important factor, due to the fact that PRS is also repeatedly seen in refugees and witnesses to violence.[2] The helplessness and hopelessness can transmit from parents to children and from children to parents as they watch one another battling with uncontrollable proceedings.[2] Viral infections are repeatedly seen to be a factor in PRS; many cases are thought to begin with a viral infection. There have been other theories regarding the cause of PRS, for instance, the psychodynamic theory of fatal mothering and a potential neurobiological role of the insula.[2] Von Folsach and Montgomery put forth four essential risk factors: (1) a premorbid personality, (2) a history of child psychiatric problems, (3) parental psychiatric problems and (4) sudden stressful events.[2] PRS children are typically known to be perfectionists, conscientious and high achievers. When these children are put in stressful events that they feel they cannot control, they go into a state of learned helplessness. Previous child psychiatric problems can designate a susceptibility to develop PRS when put in stressful situations, and parental psychiatric problems may influence the parents' capability to support and care for their children.[2] MechanismSeligman's (1990) model of learned helplessness embodies that the learned expectation of having no control over matters in the environment is met with a generalized passivity response.[6] It is speculated that the interactions between the child and events in their surroundings can end in the child encountering feelings of helplessness and therefore, a loss of personal hopefulness.[6] The patient is scared to take part in the world and feels inadequate in facing internal and external experiences, which he or she experiences through the world and thinking about his or her emotional encounters.[6] This model is effective in explaining the degradation in children with PRS when trying to rehabilitate them. If the child or adolescent is experiencing the treatment intervention as forceful, then their feeling of helplessness increases.[6]DiagnosisThompson and Nunn were the first to introduce diagnostic criteria for PRS in 1997. Diagnostic criteria consists of:[2]
TreatmentNo evidence-based treatment exist. Treatment generally incorporates a multidisciplinary team approach and a controlled yet flexible management plan with a visible basis engaged over months to years.[2] Recovery from pervasive refusal syndrome is slow, usually demands one year after diagnosis and introduction of treatment, but many children have a complete recovery and relapse is almost never seen. Adding pressure on recovery times can set a person back.[26] Inpatient treatmentHospitalization in a child and adolescent psychiatric unit is often required.[2] Outpatient treatment does display symptom-free periods, but relapses of short-lived episodes of depressive symptoms or anorexia are observed.[2] It is therefore necessary to partake in inpatient treatment. Treatment ought to involve gentle loving care. The person treating the patient must be very sensitive and tolerant because it takes a long period of time for the patient to get better, and putting pressure on them adds severity to their condition.[2] It frequently takes several months of treatment before it is likely to employ a very steady rehabilitation programme.[2]Role of the familyThe role of the family in the treatment process is vital yet complicated, given that withdrawal of the child from therapy is a key problem. It is important to include the family of the patient in the treatment process as it eases family anxiety and distress.[2] Nonetheless, it is important to create some space because too much involvement of the family may be counterproductive. Medication seems to play a very restricted part in the management of pervasive refusal syndrome (PRS), having importance in the treatment of comorbid disorders only, for example antidepressants for comorbid depression.[2] EpidemiologyPervasive refusal syndrome is more frequently seen in girls than boys. The average age of onset is 7-15.[2] Affected children are usually high achievers with high self-expectations, fears of failure, and difficulty dealing with failure to achieve personal standards.[7] The onset of PRS is usually acute.[7] References1. ^{{cite journal | author=Lask B | year=2004 | title=Pervasive Refusal Syndrome among Asylum-seeking Children | journal=Advances in Psychiatric Treatment | publisher=The Royal College of Psychiatrists | volume=10 | pages=153–159 | url=http://apt.rcpsych.org/cgi/content/abstract/10/2/153 | accessdate=2011-06-10 | issue=2 | doi=10.1192/apt.10.2.153}} 2. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 {{cite journal |vauthors=Jaspers T, Hanssen GM, van der Valk JA, Hanekom JH, van Well GT, Schieveld JN | title=Pervasive refusal syndrome as part of the refusal-withdrawal-regression spectrum: critical review of the literature illustrated by a case report | journal=European Child & Adolescent Psychiatry |date=November 2009 | volume=18 | issue=11 | pages=645–651 | doi=10.1007/s00787-009-0027-6 | pmid=19458987 | pmc=2762526}} 3. ^{{cite journal |vauthors=Lask B, Britten C, Kroll L, Magagna J, Tranter M | title=Children with pervasive refusal | journal=Archives of Disease in Childhood | year=1991 | volume=66 | pages=866–869 | doi=10.1136/adc.66.7.866 | pmc=1793258 }} 4. ^1 2 3 {{cite book |last=Coghill |first=David |author2=Sally Bonnar |author3=Sandra Duke |author4=Sarah Seth |author5=Johnny Graham |title=Child and Adolescent Psychiatry |year=2009 |publisher=Oxford University Press |page=310 |url=https://books.google.com/?id=pcUeLW9O0ZgC&dq=pervasive+refusal+syndrome+symptoms |isbn=9780199234998}} 5. ^1 2 3 4 {{cite journal |last=Searcy |first=Eileen |title=Helping the patient who has pervasive development disorder |journal=Journal of the American Academy of Physician Assistants |year=2001 |volume=14 |issue=10 |page=39 |url=http://search.proquest.com/docview/232486468}} 6. ^1 2 3 {{cite book |last=Magagna |first=J. |title=The Silent Child: Communication Without Words |year=2012 |publisher=Karnac Books |location=London |page=141 |url=https://books.google.com/?id=fflw-NRtuRQC&dq=pervasive+refusal+syndrome+and+learnt+helplessness |isbn=9781855755185}} 7. ^1 2 {{cite book |last=Sharlin |first=Judith |last2=Edelstein |first2=Sari |title=Essentials of Life Cycle Nutrition |year=2010 |publisher=Jones and Bartlett Learning |location=Canada |page=188 |isbn=9780763777920 |url=https://books.google.com/?id=xPyuUPlX7FMC&dq=pervasive+refusal+syndrome+prevalence}} External links{{Medical resources| ICD10 = | ICD9 = | ICDO = | OMIM = | DiseasesDB = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeSH = | GeneReviewsNBK = | GeneReviewsName = | Orphanet = }} 2 : Emotional and behavioral disorders in childhood and adolescence|Syndromes |
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