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词条 Protostadienol synthase
释义

  1. References

  2. External links

{{Infobox enzyme
| Name = Protostadienol synthase
| EC_number = 5.4.99.32
| CAS_number =
| IUBMB_EC_number = 5/4/99/32
| GO_code =
| image =
| width =
| caption =
}}Protostadienol synthase ({{EC number|5.4.99.32}}, PdsA, (S)-2,3-epoxysqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming]) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming).[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene (17Z)-protosta-17(20),24-dien-3beta-ol

(17Z)-Protosta-17(20),24-dien-3beta-ol is a precursor of the steroidal antibiotic helvolic acid.

References

1. ^{{cite journal | vauthors = Lodeiro S, Xiong Q, Wilson WK, Ivanova Y, Smith ML, May GS, Matsuda SP | title = Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus | journal = Organic Letters | volume = 11 | issue = 6 | pages = 1241–4 | date = March 2009 | pmid = 19216560 | doi = 10.1021/ol802696a }}

External links

  • {{MeshName|Protostadienol+synthase}}
{{Mutases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}

1 : EC 5.4.99

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