QDS may refer to

• the Semitic triliteral Q-D-Š "sacred"
• Quantum digital signature
• a three letter acronym for 'every six hours,' from the Latin quater die sumendus.

• 1999 ACC Men's Basketball Tournament
• 1999 a.d.
• 1999 Adur District Council election
• 1999 AFL draft
• 1999 AFL Grand Final
• 1999 AFL season
• 1999 AFL Women's National Championships
• 1999 African Footballer of the Year
• 1999 Air Botswana ATR 42 crash
• 1999 album
• 1999 ALCS
• 1999 ALDS
• 1999 All-Africa Games
• 1999 All England Open Badminton Championships
• 1999 Allerdale Borough Council election
• 1999 All-Ireland Senior Hurling Championship
• 1999 Alnwick District Council election
• 1999 Alpine Skiing World Championships
• 1999 Amber Valley Borough Council election
• 1999 American Inventors Protection Act
• 1999 American League Championship Series
• 1999 American League Division Series
• 1999 American Le Mans Series
• 1999 American Music Awards
• 1999 American Society of Cinematographers Awards