| 词条 | Rimeporide |
| 释义 |
| IUPAC_name = N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine | image = Rimeporide skeletal.svg | alt = | caption = | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_AU_comment = | legal_CA = | legal_NZ = | legal_UK = | legal_US = | legal_UN = | legal_status = Experimental | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | metabolites = | onset = | elimination_half-life = | duration_of_action = | excretion = | CAS_number = 187870-78-6 | ATCvet = | ATC_prefix = none | ATC_suffix = | PubChem = 9799487 | ChemSpiderID = 7975252 | DrugBank = | ChEMBL = 2107802 | UNII = QH6B4V5743 | C=11 | H=15 | N=3 | O=5 | S=2 | smiles = Cc1cc(c(cc1C(=O)NC(=N)N)S(=O)(=O)C)S(=O)(=O)C | StdInChI=1S/C11H15N3O5S2/c1-6-4-8(20(2,16)17)9(21(3,18)19)5-7(6)10(15)14-11(12)13/h4-5H,1-3H3,(H4,12,13,14,15) | StdInChIKey = GROMEQPXDKRRIE-UHFFFAOYSA-N }}Rimeporide is an experimental drug for the treatment of Duchenne muscular dystrophy, being developed by the EspeRare foundation. it has been granted orphan drug status by the European Medicines Agency.[2] Mechanism of actionThe substance blocks an ion pump called sodium–hydrogen antiporter 1 (NHE-1). While the exact mechanism is unknown, it is speculated that inhibition of this pump reduces sodium and calcium overload in cells of Duchenne patients. HistoryRimeporide was designed as a treatment for chronic heart failure. It was unsuccessful in Phase I clinical trials, but was tolerated well by volunteers. Subsequently, the drug was sold to EspeRare, a Swiss nonprofit organisation[4] that aims at developing drugs for rare diseases. {{as of|2015|5}}, the substance is in preclinical development for Duchenne. See alsoOther drugs for Duchenne muscular dystrophy
References1. ^1 {{cite web|url=http://esperare.org/en/our-mission-and-vision|title=Our mission and vision|publisher=EspeRare|accessdate=23 July 2015}} [1][2]2. ^1 {{cite news|url=http://esperare.org/en/news/esperares-rimeporide-receives-orphan-drug-designation-duchenne-muscular-dystrophy|title=EspeRare’s Rimeporide receives Orphan Drug Designation in Duchenne Muscular Dystrophy|publisher=EspeRare|date=4 May 2015}} }} 4 : Muscular dystrophy|Orphan drugs|Acylguanidines|Sulfones |
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