AYS or Ays may refer to:

• Ay dynasty, a ruling lineage in south India
• About Your Sexuality, American sex education materials
• The National Rail code for Aylesbury railway station in Aylesbury, United Kingdom
• The Eyeish people, also known as Ays, a Native American tribe from Texas
• Waycross-Ware County Airport, IATA code AYS, airport in Georgia, United States
• Adventist Youth Society
• Allyson Young Schwartz U.S. Representative for Pennsylvania's 13th congressional district
• Amaysim Australia Ltd, a company listed on the Australian Securities Exchange.

• South Daytona, Fl
• South Dayton (village), New York
• Southdean
• South Dearborn Street-Printing House Row Historic District
• South Dearborn Street-Printing House Row North Historic District
• South Delhi, New Delhi
• South Dell
• South Delridge, Seattle
• South Dennis, New Jersey
• South Dennis station
• South Derbyshire District Council
• South Derbyshire Football Association
• South Derry
• South Devon College
• South Devon Railway (disambiguation)
• South Devon Railway Trust
• South Dildo
• South Dinajpur district
• South Direction Island (Queensland)
• South District, Israel
• South District (Israel)
• South District, Taichung
• South District, Tainan
• South Division (NAHL)
• South Division One (shinty)