TBZ can refer to:

• A computer file, the result of tar and bzip2 operations.
• Tetrabenazine, a drug
• Thiabendazole, a parasiticide
• Tabriz International Airport

• IOU (debt)
• Ioueldaob
• I.O.U. (Freeez song)
• IOUG
• Iouik
• Ioukhari Veisalou
• I.O.U. (Lee Greenwood song)
• Ioulia Shapiro
• Ioulia Timochenko
• Ioulida
• Ioulis
• I.O.U. Live
• Ioun
• Iouri Baskakov
• Iouri Iatsev
• Iouri Podladtchikov
• Iouri Trofimov
• IOUs
• I.O.U.S.A.
• I O U S A
• I.O.U.S.A
• IOUSA
• I.O.U.S.A. - The Book
• I.O.U.S.A. – The Book
• Ioustinianos I