| Year | Title | Role | Notes |
|---|
| 1970 | Joe | Melissa Compton |
| 1971 | Lady Liberty | Sally |
| 1971 | The Apprentice | Elizabeth Hawkins |
| 1974 | Lovin' Molly | Sarah |
| 1974 | The Front Page | Peggy Grant |
| 1975 | The Great Waldo Pepper | Mary Beth |
| 1975 | The Rocky Horror Picture Show | Janet Weiss |
| 1976 | One Summer Love | Chloe |
| 1977 | Checkered Flag or Crash | C.C. Wainwright |
| 1977 | The Other Side of Midnight | Catherine Alexander Douglas |
| 1977 | The Great Smokey Roadblock | Ginny | Also co-producer |
| 1978 | Pretty Baby | Hattie |
| 1978 | King of the Gypsies | Rose |
| 1979 | Something Short of Paradise | Madeline Ross |
| 1980 | Atlantic City | Sally Matthews |
| 1980 | Loving Couples | Stephanie Beck |
| 1982 | Tempest | Aretha Tomalin |
| 1983 | The Hunger | Sarah Roberts |
| 1984 | The Buddy System | Emily Price |
| 1985 | Compromising Positions | Judith Singer |
| 1987 | The Witches of Eastwick | Jane Spofford |
| 1988 | Bull Durham | Annie Savoy |
| 1988 | Sweet Hearts Dance | Sandra Boon |
| 1989 | The January Man | Christine Starkey |
| 1989 | A Dry White Season | Melanie Bruwer |
| 1990 | White Palace | Nora Baker |
| 1991 | Thelma & Louise | Louise Sawyer |
| 1992 | The Player | Herself |
| 1992 | Light Sleeper | Ann |
| 1992 | Bob Roberts | Tawna Titan |
| 1992 | Lorenzo's Oil | Michaela Odone |
| 1994 | The Client | Regina "Reggie" Love |
| 1994 | Little Women | Margaret "Marmee" March |
| 1994 | Safe Passage | Margaret "Mag" Singer |
| 1995 | Dead Man Walking | Sister Helen Prejean |
| 1996 | James and the Giant Peach | Miss Spider (voice) |
| 1998 | Twilight | Catherine Ames |
| 1998 | Illuminata | Calimene |
| 1998 | Stepmom | Jackie Harrison | Also executive producer |
| 1999 | Our Friend, Martin | Mrs. Clark (voice) | Direct-to-video |
| 1999 | Cradle Will Rock | Margherita SarfattI |
| 1999 | Anywhere but Here | Adele August |
| 2000 | Joe Gould's Secret | Alice Neel |
| 2000 | The Movie | Coco LaBouche (voice) |
| 2001 | Cats & Dogs | Ivy (voice) |
| 2001 | Goodnight Moon | Narrator | Short film |
| 2002 | Igby Goes Down | Mimi Slocumb |
| 2002 | The Banger Sisters | Lavinia Kingsley |
| 2002 | Moonlight Mile | Jojo Floss | Also executive producer |
| 2002 | Little Miss Spider | Narrator | Short film |
| 2004 | Noel | Rose Collins |
| 2004 | Jiminy Glick in Lalawood | Herself | Cameo |
| 2004 | Shall We Dance | Beverly Clark |
| 2004 | Alfie | Liz |
| 2005 | Elizabethtown | Hollie Baylor |
| 2005 | Romance & Cigarettes | Kitty Kane Murder |
| 2006 | Irresistible | Sophie Hartley |
| 2007 | Mr. Woodcock | Beverly Farley |
| 2007 | In the Valley of Elah | Joan Deerfield |
| 2007 | Enchanted | Queen Narissa |
| 2007 | Emotional Arithmetic | Melanie Lansing Winters |
| 2008 | Speed Racer | Mom Racer |
| 2008 | Middle of Nowhere | Rhonda Berry |
| 2009 | The Greatest | Grace Brewer |
| 2009 | Leaves of Grass | Daisy Kincaid |
| 2009 | Solitary Man | Nancy Kalmen |
| 2009 | The Lovely Bones | Grandma Lynn |
| 2010 | Money Never Sleeps | Sylvia Moore |
| 2010 | Peacock | Fanny Crill |
| 2012 | Jeff, Who Lives at Home | Sharon Thompkins |
| 2012 | Robot & Frank | Jennifer |
| 2012 | That's My Boy | Mary McGarricle |
| 2012 | Arbitrage | Ellen Miller |
| 2012 | Cloud Atlas | Madame Horrox / Older Ursula / Yosouf Suleiman / Abbess |
| 2012 | The Company You Keep | Sharon Solarz |
| 2013 | Snitch | Joanne Keeghan |
| 2013 | Irwin & Fran | Narrator |
| 2013 | The Big Wedding | Bebe McBride |
| 2013 | The Last of Robin Hood | Florence Aadland |
| 2014 | Tammy | Pearl Balzen |
| 2014 | Ping Pong Summer | Randy Jammer |
| 2014 | The Calling | Hazel Micallief |
| 2015 | Hell and Back | Barb the Angel (voice) |
| 2015 | The Meddler | Marnie Minervini | Also executive producer |
| 2015 | 3 Generations | Dolly |
| 2015 | The Other Side of the Lake the Purple Girl | Herself |
| 2016 | Zoolander 2 | Herself | Uncredited cameo |
| 2016 | April and the Extraordinary World | Chimene (voice) | English dub |
| 2016 | Mothers and Daughters | Millie |
| 2016 | Spark | Bananny (voice) |
| 2016 | Ace the Case | Detective Dottie Wheel |
| 2016 | My Entire High School Sinking Into the Sea | Lunch Lady Lorraine (voice) |
| 2017 | A Bad Moms Christmas | Isis Dunkler |
| 2018 | The Death and Life of John F. Donovan | Grace Donovan |
| 2018 | Viper Club | Helen |
| 2019 | Going Places | Completed |
| TBA | Blackbird | Lily | Post-production |
| Year | Title | Role | Notes |
|---|
| 1971 | A World Apart | Patrice Kahlman | 1 episode |
| 1971 | Counselor at Law | Joyce | Episode: "Burden of Proof" |
| 1972 | Search for Tomorrow | Sarah Fairbanks | Unknown episodes |
| 1974 | F. Scott Fitzgerald and 'The Last of the Belles' | Ailie Calhoun | Television film |
| 1974 | {{sortname>The|Satan Murders|nolink=1}} | Kate | Television film |
| 1974 | June Moon | Eileen | Television film |
| 1974 | {{sortname>The|Rimers of Eldritch}} | Pasty Johnson | Television film |
| 1975 | {{sortname>The|Haunting of Rosalind|nolink=1}} | Television film |
| 1982 | Who Am I This Time? | Helene Shaw | Episode: "American Playhouse" |
| 1984 | Oxbridge Blues | Natalie | Episode: "He'll See You Now" |
| 1984 | Faerie Tale Theatre | Beauty | Episode: "Beauty And The Beast" |
| 1985 | A.D | Livilla | 5 episodes |
| 1985 | Mussolini and I | Edda Mussolini Ciano | Television film |
| 1986 | Women of Valor | Col. Margaret Ann Jessup | Television film |
| 1994 | All Star 25th Birthday: Stars and Street Forever! | Bitsy | Television special |
| 1995 | {{sortname>The|Simpsons}} | Ballet Teacher (voice) | Episode: "Homer vs. Patty and Selma" |
| 1999 | Earthly Possessions | Charlotte Emory | Television film |
| 2001 | Friends | Cecilia Monroe/Jessica Lockhart | Episode: "The One With Joey's New Brain" |
| 2001 | Cool Women in History | Herself (host) | Season 1 |
| 2002 | Malcolm in the Middle | Meg | 2 episodes |
| 2003 | A Woman's Survival at the South Pole | Dr. Jerri Nielsen | Television film |
| 2003 | Frank Herbert's Children of Dune | Princess Wensicia | 3 episodes |
| 2004 | Troy: The Passion of Helen | Herself (host) | Television documentary |
| 2005 | The Exonerated | Sunny Jacobs | Television film |
| 2005 | Mad TV | Various roles | 2 episodes |
| 2006 | The Simpsons | Herself (voice) | Episode: "Bart Has Two Mommies" |
| 2006–2007 | Rescue Me | Alicia Green | 6 episodes |
| 2007 | Bernard and Doris | Doris Duke | Television film |
| 2009, 2011 | Saturday Night Live | Mother | Uncredited
2 episodes |
| 2009 | ER | Nora | Episode: "Old Times" |
| 2010 | You Don't Know Jack | Janet Good | Television film |
| 2011–2012 | 30 Rock | Lynn Onkman | 2 episodes |
| 2012 | The Big C | Joy the Joyologist | 6 episodes |
| 2012 | Louie | Herself | Episode: "Late Night Part 3" |
| 2013–2014 | Mike & Molly | J.C. Small | 2 episodes |
| 2014 | Doll & Em | Herself | Episode: "Two" |
| 2015 | The Secret Life of Marilyn Monroe | Gladys | 2 episodes |
| 2015 | Moonbeam City | Ice Ivory (voice) | Episode: "The Legend of Circuit Lake" |
| 2016 | Cassius and Clay | (voice) | Pilot |
| 2016–2017 | Skylanders Academy | Golden Queen (voice) | 6 episodes |
| 2016 | American Dad! | Mrs. Jasperterian (voice) | Episode: "Portrait of Francine's Genitals" |
| 2017 | Feud: Bette and Joan | Bette Davis | 8 episodes; also co-producer |
| 2017–2019 | Ray Donovan | Samantha Winslow | 16 episodes |
| 2017 | Rick and Morty | Dr. Wong (voice) | Episode: "Pickle Rick" |
| 2017–2018 | Neo Yokio | Aunt Agatha (voice) | 7 episodes |
| Year | Title | Role |
|---|
| 1983 | When the Mountains Tremble | Herself |
| 1990 | Through the Wire | Narrator |
| 1993 | Wilderness: The Last Stand | Narrator |
| 1994 | School of the Americas Assassins | Narrator |
| 1995 | The Celluloid Closet | Herself |
| 1995 | One Woman One Vote | Narrator |
| 1996 | George Seldes and the American Press | Narrator |
| 1997 | {{sortname>The|Need to Know|nolink=1}} | Narrator |
| 1997 | Father Roy: Inside the School of Assassins | Narrator |
| 1997 | 187: Documented | Narrator |
| 1999 | For Love of Julian | Narrator |
| 2000 | Light Keeps Me Company | Herself |
| 2000 | Iditarod: A Far Distant Place | Narrator |
| 2000 | Mythos | Narrator |
| 2000 | This Is What Democracy Looks Like | Narrator |
| 2000 | Dying to be Thin | Narrator |
| 2001 | Uphill All the Way | Narrator |
| 2001 | 900 Women | Narrator |
| 2001 | {{sortname>The|Shaman's Apprentice|nolink=1}} | Narrator |
| 2001 | Rudyland | Narrator |
| 2001 | Rock City | Narrator |
| 2001 | Ghosts of Attica | Narrator |
| 2001 | The Party's Over | Herself |
| 2002 | {{sortname>The|Next Industrial Revolution|nolink=1}} | Narrator |
| 2002 | Tibet: Cry of the Snow Lion | Narrator |
| 2003 | XXI Century | Herself |
| 2003 | {{sortname>The|Nazi Officer's Wife|nolink=1}} | Narrator |
| 2003 | Burma: Anatomy of Terror | Narrator |
| 2003 | Journey of the Heart: The Life of Henri Nouwen | Narrator |
| 2004 | Fragile Hopes from the Killing Fields | Narrator |
| 2005 | {{sortname>A|Whale in Montana|nolink=1}} | Narrator |
| 2005 | On the Line: Dissent in an Age of Terrorism | Herself |
| 2006 | Secrets of the Code | Narrator |
| 2006 | Christa McAuliffe: Reach for the Stars | Narrator |
| 2006 | Home | Herself |
| 2007 | This Child of Mine | Narrator |
| 2007 | Beyond Wiseguys: Italian Americans & the Movies | Herself |
| 2007 | Coming Home | Herself |
| 2009 | PoliWood | Herself |
| 2010 | Who Do You Think You Are? | Herself |
| 2014 | Unity | Narrator |
| 2015 | Connected | Herself |
| 2017 | Bombshell: The Hedy Lamarr Story | Executive producer only |
| 2017 | Soufra | Executive producer only |
| 2017 | Up To Us | Herself |
| 2018 | The Survivor's Guide to Prison | Narrator; also producer |
| 2018 | American Mirror | Herself, model |
| 2018 | Death Row Stories | Narrator; also producer |
1. ^{{cite web | url=http://www.eurogamer.net/articles/2012-08-03-dishonoured-cast-includes-video-game-debutant-susan-sarandon | title=Dishonoured cast includes video game debutant Susan Sarandon | publisher=Eurogamer | date=August 3, 2012 | accessdate=January 24, 2015 | author=Purchese, Robert}}
2. ^{{cite AV media|url=https://www.youtube.com/watch?v=tkaEpUBUQDw|title=JUSTICE - FIRE|website=YouTube|publisher=Justice|date=November 30, 2016|accessdate=February 21, 2017}}
3. ^{{cite web |last1=Nordine |first1=Michael |title=Jay-Z Releases Three New ‘4:44’ Music Videos With Help From Susan Sarandon, Ron Perlman, and His Own Mother — Watch |url=https://www.indiewire.com/2017/11/jay-z-444-music-videos-susan-sarandon-ron-perlman-legacy-1201900852/ |website=indiewire.com |publisher=Penske Business Media |accessdate=2019-03-09}}