| 词条 | Tylonycteris bat coronavirus HKU4 |
| 释义 |
| image = | image_alt = | image_caption = | parent = Merbecovirus | species = Tylonycteris bat coronavirus HKU4 | authority = | synonyms = | synonyms_ref = | subdivision_ranks = | subdivision = }}Tylonycteris bat coronavirus HKU4 (Bat-CoV HKU4) is an enveloped, positive sense, single-stranded RNA mammalian Group 2 betacoronavirus that has been found to be genetically related to the Middle East respiratory syndrome-related coronavirus (MERS-CoV) that is responsible for the 2012 Middle East respiratory syndrome-related coronavirus outbreaks in Saudi Arabia, Jordan, United Arab Emirates, the United Kingdom, France, and Italy.[1][2][3][4] TransmissionThe exact means of transmission to humans is not yet well known. However, it has been demonstrated that betaCoV's including HKU4 have the propensity to recombine and cause interspecies transmission. However, this is not seen in Group C betaCov's to which MERS-CoV is most closely related.[5] See also
References1. ^{{cite journal |doi=10.1038/emi.2012.45 |title=Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5 |year=2012 |last1=Woo |first1=Patrick CY |last2=Lau |first2=Susanna KP |last3=Li |first3=Kenneth SM |last4=Tsang |first4=Alan KL |last5=Yuen |first5=Kwok-Yung |journal=Emerging Microbes & Infections |volume=1 |issue=11 |pages=e35– |pmc=3630921 |pmid=26038405}} 2. ^{{cite journal |doi=10.1056/NEJMoa1211721 |title=Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia |year=2012 |last1=Zaki |first1=Ali M. |last2=Van Boheemen |first2=Sander |last3=Bestebroer |first3=Theo M. |last4=Osterhaus |first4=Albert D.M.E. |last5=Fouchier |first5=Ron A.M. |journal=New England Journal of Medicine |volume=367 |issue=19 |pages=1814–20 |pmid=23075143}} 3. ^{{cite journal |doi=10.1016/j.virol.2006.02.041 |title=Molecular diversity of coronaviruses in bats |year=2006 |last1=Woo |first1=Patrick C.Y. |last2=Lau |first2=Susanna K.P. |last3=Li |first3=Kenneth S.M. |last4=Poon |first4=Rosana W.S. |last5=Wong |first5=Beatrice H.L. |last6=Tsoi |first6=Hoi-wah |last7=Yip |first7=Bethanie C.K. |last8=Huang |first8=Yi |last9=Chan |first9=Kwok-Hung |last10=Yuen |first10=Kwok-Yung |journal=Virology |volume=351 |pages=180–7 |pmid=16647731 |issue=1}} 4. ^{{cite journal |doi=10.1128/JVI.01055-13 |title=Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus |year=2013 |last1=Lau |first1=S. K. P. |last2=Li |first2=K. S. M. |last3=Tsang |first3=A. K. L. |last4=Lam |first4=C. S. F. |last5=Ahmed |first5=S. |last6=Chen |first6=H. |last7=Chan |first7=K.-H. |last8=Woo |first8=P. C. Y. |last9=Yuen |first9=K.-Y. |journal=Journal of Virology |volume=87 |issue=15 |pages=8638–50 |pmid=23720729 |pmc=3719811 }} 5. ^{{cite journal |doi=10.3390/v2081803 |title=Coronavirus Genomics and Bioinformatics Analysis |year=2010 |last1=Woo |first1=Patrick C. Y. |last2=Huang |first2=Yi |last3=Lau |first3=Susanna K. P. |last4=Yuen |first4=Kwok-Yung |journal=Viruses |volume=2 |issue=8 |pages=1804–20 |pmid=21994708 |pmc=3185738}} External links
2 : Betacoronaviruses|Animal viral diseases |
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