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词条 WIPI1
释义

  1. Structure and function

  2. See also

  3. References

  4. Further reading

{{Infobox_gene}}WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a protein that in humans is encoded by the WIPI1 gene.[1][2][3]

Structure and function

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein–protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.[1][3]

See also

  • WIPI protein family

References

1. ^1 {{cite web | title = Entrez Gene: WD repeat domain| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55062| accessdate = }}
2. ^{{cite journal |vauthors=Jeffries TR, Dove SK, Michell RH, Parker PJ | title = PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49 | journal = Mol. Biol. Cell | volume = 15 | issue = 6 | pages = 2652–63 |date=June 2004 | pmid = 15020712 | pmc = 420090 | doi = 10.1091/mbc.E03-10-0732 | url = | issn = }}
3. ^1 {{cite journal |vauthors=Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A | title = WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy | journal = Oncogene | volume = 23 | issue = 58 | pages = 9314–25 |date=December 2004 | pmid = 15602573 | doi = 10.1038/sj.onc.1208331 | url = | issn = }}

Further reading

{{refbegin }}
  • {{cite journal |vauthors=Chasman DI, Paré G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Mälarstig A, Ordovas JM, Ripatti S, Parker AN, Miletich JP, Ridker PM | title = Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis | journal = PLoS Genet. | volume = 5 | issue = 11 | pages = e1000730 |date=November 2009 | pmid = 19936222 | pmc = 2777390 | doi = 10.1371/journal.pgen.1000730 | url = | issn = }}
  • {{cite journal |vauthors=Behrends C, Sowa ME, Gygi SP, Harper JW | title = Network organization of the human autophagy system | journal = Nature | volume = 466 | issue = 7302 | pages = 68–76 |date=July 2010 | pmid = 20562859 | pmc = 2901998 | doi = 10.1038/nature09204 | url = | issn = }}
  • {{cite journal |vauthors=Proikas-Cezanne T, Ruckerbauer S, Stierhof YD, Berg C, Nordheim A | title = Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy | journal = FEBS Lett. | volume = 581 | issue = 18 | pages = 3396–404 |date=July 2007 | pmid = 17618624 | doi = 10.1016/j.febslet.2007.06.040 | url = | issn = }}
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