| 词条 | Unsealed source radiotherapy |
| 释义 |
Name = Unsealed source radiotherapy | Image = | Caption = | ICD10 = | ICD9 = {{ICD9proc|92.28}} | MeshID = | OPS301 = | OtherCodes = | HCPCSlevel2 = }}Unsealed source radiotherapy (also known as unsealed source radionuclide therapy (RNT) or molecular radiotherapy) uses radioactive substances called radiopharmaceuticals to treat medical conditions, particularly cancer. These are introduced into the body by various means (injection or ingestion are the two most commonplace) and localise to specific locations, organs or tissues depending on their properties and administration routes. This includes anything from a simple compound such as sodium iodide that locates to the thyroid via trapping the iodide ion, to complex biopharmaceuticals such as recombinant antibodies which are attached to radionuclides and seek out specific antigens on cell surfaces.[1][2] As such, this is a type of targeted therapy which uses the physical, chemical and biological properties of the radiopharmaceutical to target areas of the body for radiation treatment.[3] The related diagnostic modality of nuclear medicine employs the same principles but uses different types or quantities of radiopharmaceuticals in order to image or analyse functional systems within the patient. RNT contrasts with sealed-source therapy (brachytherapy) where the radionuclide remains in a capsule or metal wire during treatment and needs to be physically placed precisely at the treatment position.[4] Clinical useIodine-131{{see also|Iodine-131#Medical use}}Iodine-131 (131I) is the most common RNT worldwide and uses the simple compound sodium iodide with a radioactive isotope of iodine. The patient (human or animal) may ingest an oral solid or liquid amount or receive an intravenous injection of a solution of the compound. The iodide ion is selectively taken up by the thyroid gland. Both benign conditions like thyrotoxicosis and certain malignant conditions like papillary thyroid cancer can be treated with the radiation emitted by radioiodine.[5] Iodine-131 produces beta and gamma radiation. The beta radiation released damages both normal thyroid tissue and any thyroid cancer that behaves like normal thyroid in taking up iodine, so providing the therapeutic effect, whilst most of the gamma radiation escapes the patient's body.[6]Most of the iodine not taken up by thyroid tissue is excreted through the kidneys into the urine. After radioiodine treatment the urine will be radioactive or 'hot', and the patients themselves will also emit gamma radiation. Depending on the amount of radioactivity administered, it can take several days for the radioactivity to reduce to the point where the patient does not pose a radiation hazard to bystanders. Patients are often treated as inpatients and there are international guidelines, as well as legislation in many countries, which govern the point at which they may return home.[7] MIBG131I-MIBG (metaiodobenzylguanidine) is used for the treatment of phaeochromocytoma and neuroblastoma.[8]Bone metastasis{{see also|Targeted alpha-particle therapy}}Radium-223 chloride, strontium-89 chloride and samarium-153 EDTMP are used to treat secondary cancer in the bones.[9][10] Radium and strontium mimic calcium in the body.[11] Samarium is bound to tetraphosphate EDTMP, phosphates are taken up by osteoblastic (bone forming) repairs that occur adjacent to some metastatic lesions.[12]Phosphorus-32Beta emitting Phosphorus-32 (32P), as sodium phosphate, is used to treat overactive bone marrow, in which it is otherwise naturally metabolised.[13][14][15]Yttrium-9090Y colloidAn yttrium-90 (90Y) colloidal suspension is used for radiosynovectomy in the knee joint.[16] 90Y spheres{{main|Selective internal radiation therapy}}90Y in the form of a resin or glass spheres can be used to treat primary and metastic liver cancers.[17]Experimental antibody based methodsAt the Institute for Transuranium Elements (ITU) work is being done on alpha-immunotherapy, this is an experimental method where antibodies bearing alpha isotopes are used. Bismuth-213 is one of the isotopes which has been used. This is made by the alpha decay of Ac-225. The generation of one short-lived isotope from longer lived isotope is a useful method of providing a portable supply of a short-lived isotope. This is similar to the generation of technetium-99m by a technetium generator. The actinium-225 is made by the irradiation of radium-226 with a cyclotron.[18] References1. ^{{cite journal|last1=Buscombe|first1=J.|last2=Navalkissoor|first2=S.|title=Molecular radiotherapy|journal=Clinical Medicine|date=1 August 2012|volume=12|issue=4|pages=381–386|doi=10.7861/clinmedicine.12-4-381|pmid=22930888|pmc=4952132|doi-access=free}} {{Radiation oncology}}{{Radiopharmaceuticals}}2. ^{{cite journal |last1=Volkert |first1=Wynn A. |last2=Hoffman |first2=Timothy J. |title=Therapeutic Radiopharmaceuticals |journal=Chemical Reviews |volume=99 |issue=9 |year=1999 |pages=2269–2292 |doi=10.1021/cr9804386 |pmid=11749482}} 3. ^{{cite book|last1=Nicol|first1=Alice|last2=Waddington|first2=Wendy|title=Dosimetry for radionuclide therapy|date=2011|publisher=Institute of Physics and Engineering in Medicine|location=York|isbn=9781903613467}} 4. ^{{cite book|last1=Editor|first1=Elizabeth A. Martin|title=A dictionary of nursing|date=2014|publisher=Oxford University Press|location=Oxford|isbn=9780199666379|edition=6th|doi=10.1093/acref/9780199666379.001.0001}} 5. ^{{cite journal|last1=Silberstein|first1=E. B.|last2=Alavi|first2=A.|last3=Balon|first3=H. R.|last4=Clarke|first4=S. E. M.|last5=Divgi|first5=C.|last6=Gelfand|first6=M. J.|last7=Goldsmith|first7=S. J.|last8=Jadvar|first8=H.|last9=Marcus|first9=C. S.|last10=Martin|first10=W. H.|last11=Parker|first11=J. A.|last12=Royal|first12=H. D.|last13=Sarkar|first13=S. D.|last14=Stabin|first14=M.|last15=Waxman|first15=A. D.|title=The SNMMI Practice Guideline for Therapy of Thyroid Disease with 131I 3.0|journal=Journal of Nuclear Medicine|date=11 July 2012|volume=53|issue=10|pages=1633–1651|doi=10.2967/jnumed.112.105148|pmid=22787108}} 6. ^{{cite book|last1=IAEA|title=Manual on therapeutic uses of iodine-131|date=1996|publisher=International Atomic Energy Agency|location=Vienna|page=7|url=http://www.iaea.org/inis/collection/NCLCollectionStore/_Public/28/027/28027984.pdf}} 7. ^{{cite book|last1=IAEA|last2=ICRP|title=Release of patients after radionuclide therapy|date=2009|publisher=International Atomic Energy Agency|location=Vienna, Austria|isbn=978-92-0-108909-0|url=http://www-pub.iaea.org/books/iaeabooks/8179/Release-of-Patients-After-Radionuclide-Therapy}} 8. ^{{cite journal|last1=Sharp|first1=Susan E.|last2=Trout|first2=Andrew T.|last3=Weiss|first3=Brian D.|last4=Gelfand|first4=Michael J.|title=MIBG in Neuroblastoma Diagnostic Imaging and Therapy|journal=RadioGraphics|date=January 2016|volume=36|issue=1|pages=258–278|doi=10.1148/rg.2016150099|pmid=26761540}} 9. ^{{cite journal|last1=Den|first1=RB|last2=Doyle|first2=LA|last3=Knudsen|first3=KE|title=Practical guide to the use of radium 223 dichloride.|journal=The Canadian Journal of Urology|date=April 2014|volume=21|issue=2 Supp 1|pages=70–6|pmid=24775727}} 10. ^{{cite journal|last1=Lutz|first1=Stephen|last2=Berk|first2=Lawrence|last3=Chang|first3=Eric|last4=Chow|first4=Edward|last5=Hahn|first5=Carol|last6=Hoskin|first6=Peter|last7=Howell|first7=David|last8=Konski|first8=Andre|last9=Kachnic|first9=Lisa|last10=Lo|first10=Simon|last11=Sahgal|first11=Arjun|last12=Silverman|first12=Larry|last13=von Gunten|first13=Charles|last14=Mendel|first14=Ehud|last15=Vassil|first15=Andrew|last16=Bruner|first16=Deborah Watkins|last17=Hartsell|first17=William|title=Palliative Radiotherapy for Bone Metastases: An ASTRO Evidence-Based Guideline|journal=International Journal of Radiation Oncology*Biology*Physics|date=March 2011|volume=79|issue=4|pages=965–976|doi=10.1016/j.ijrobp.2010.11.026|pmid=21277118|doi-access=free}} 11. ^{{cite journal|last1=Goyal|first1=Jatinder|last2=Antonarakis|first2=Emmanuel S.|title=Bone-targeting radiopharmaceuticals for the treatment of prostate cancer with bone metastases|journal=Cancer Letters|date=October 2012|volume=323|issue=2|pages=135–146|doi=10.1016/j.canlet.2012.04.001|pmc=4124611|pmid=22521546}} 12. ^{{cite journal|last1=Serafini|first1=AN|title=Samarium Sm-153 lexidronam for the palliation of bone pain associated with metastases.|journal=Cancer|date=15 June 2000|volume=88|issue=12 Suppl|pages=2934–9|doi=10.1002/1097-0142(20000615)88:12+<2934::AID-CNCR9>3.0.CO;2-S|pmid=10898337}} 13. ^{{cite journal|last1=Tennvall|first1=Jan|last2=Brans|first2=Boudewijn|title=EANM procedure guideline for 32P phosphate treatment of myeloproliferative diseases|journal=European Journal of Nuclear Medicine and Molecular Imaging|date=30 March 2007|volume=34|issue=8|pages=1324–1327|doi=10.1007/s00259-007-0407-4|pmid=17396258}} 14. ^{{cite book|last1=Raj|first1=Gurdeep|title=Advanced Inorganic Chemistry Vol 1|publisher=Krishna Prakashan Media|isbn=9788187224037|page=497|url=https://books.google.com/books?id=0uwDTrxyaB8C&pg=PA497|language=en}} 15. ^{{cite book|last1=Gropper|first1=Sareen S.|last2=Smith|first2=Jack L.|title=Advanced Nutrition and Human Metabolism|publisher=Cengage Learning|isbn=978-1133104056|page=432|url=https://books.google.com/books?id=3R0Yeu79jfQC&pg=PA432|language=en|date=2012-06-01}} 16. ^{{cite journal|last1=Siegel|first1=Michael E.|last2=Siegel|first2=Herrick J.|last3=Luck|first3=James V.|title=Radiosynovectomy's clinical applications and cost effectiveness: A review|journal=Seminars in Nuclear Medicine|date=October 1997|volume=27|issue=4|pages=364–371|doi=10.1016/S0001-2998(97)80009-8|pmid=9364646}} 17. ^{{cite journal|last1=Allen|first1=Theresa M.|title=Ligand-targeted therapeutics in anticancer therapy|journal=Nature Reviews Cancer|date=October 2002|volume=2|issue=10|pages=750–763|doi=10.1038/nrc903|pmid=12360278}} 18. ^{{cite journal|last1=Morgenstern|first1=Alfred|last2=Bruchertseifer|first2=Frank|last3=Apostolidis|first3=Christos|title=Bismuth-213 and Actinium-225 – Generator Performance and Evolving Therapeutic Applications of Two Generator-Derived Alpha-Emitting Radioisotopes|journal=Current Radiopharmaceuticals|date=1 June 2012|volume=5|issue=3|pages=221–227|doi=10.2174/1874471011205030221|pmid=22642390}} 2 : Radiation therapy|Nuclear medicine |
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