| 词条 | 4-Methylphenethylacetylfentanyl |
| 释义 |
| IUPAC_name = N-[1-[2-(4-Methylphenyl)ethyl]-4-piperidinyl]-N-phenylacetamide | image = 4-Methylphenethylacetylfentanyl_structure.png | pregnancy_category = | legal_AU = | legal_CA = Schedule I | legal_UK = Class A | legal_US = | legal_status = Illegal in Arkansas | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 1071703-95-1 | ATC_prefix = | ATC_suffix = | PubChem = 91736720 | DrugBank_Ref = | DrugBank = | ChemSpiderID = 29752849 | ChEBI_Ref = | ChEBI = | UNII_Ref = | UNII = | C=22 | H=28 | N=2 | O=1 | smiles = Cc1ccc(cc1)CCN2CCC(CC2)N(C(=O)C)c3ccccc3 | StdInChI = 1S/C22H28N2O/c1-18-8-10-20(11-9-18)12-15-23-16-13-22(14-17-23)24(19(2)25)21-6-4-3-5-7-21/h3-11,22H,12-17H2,1-2H3 | StdInChIKey = BBMRIHXVAUNKEV-UHFFFAOYSA-N | synonyms = }}4-Methylphenethylacetylfentanyl (acetylfentanyl 4-methylphenethyl analog) is an opioid analgesic that is an analog (and structural isomer) of fentanyl and has been sold as a designer drug.[1] Side effectsSide effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[2] A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week.[3] Legal status4-Methylphenethylacetylfentanyl was banned in Arkansas in 2018.[4] See also
References1. ^[https://www.unodc.org/documents/scientific/Recommended_methods_for_the_identification_and_analysis_of_Fentanyl.pdf Recommended Methods for the Identification and Analysis of Fentanyl and its Analogues in Biological Specimens. United Nations Office on Drugs and Crime, November 2017] {{Opioidergics}}{{DEFAULTSORT:Methylphenethylacetylfentanyl, 4-}}2. ^{{cite journal | vauthors = Mounteney J, Giraudon I, Denissov G, Griffiths P | title = Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe | journal = The International Journal on Drug Policy | volume = 26 | issue = 7 | pages = 626–31 | date = July 2015 | pmid = 25976511 | doi = 10.1016/j.drugpo.2015.04.003 | url = http://www.ijdp.org/article/S0955-3959%2815%2900097-3/abstract }} 3. ^{{cite journal | vauthors = Armenian P, Vo KT, Barr-Walker J, Lynch KL | title = Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review | journal = Neuropharmacology | volume = | issue = | date = October 2017 | pmid = 29042317 | doi = 10.1016/j.neuropharm.2017.10.016 }} 4. ^List of Controlled Substances in Arkansas 5 : Anilides|Designer drugs|Mu-opioid agonists|Piperidines|Synthetic opioids |
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