| 词条 | Anne-Maree Pearse |
| 释义 |
| name = Anne-Maree Pearse | fields = Cytogenetics | alma_mater = University of Sydney University of Tasmania | known_for = Devil facial tumour disease | awards = 2011 Australian Museum Eureka Prize 2012 Prince Hitachi Prize }} Anne-Maree Pearse is an Australian cytogeneticist who is credited with the theory that some cancer cells can be transmissible between individuals. This is known as the Allograft Theory. Her work has focussed on devil facial tumour disease (DFTD), a contagious cancer that affects Tasmanian devils. For this she has won multiple awards, including the 2012 Prince Hitachi Prize for Comparative Oncology. EducationPearse graduated from the University of Sydney in 1972 before starting an MSc at the University of Tasmania in 1976.[1] During her Masters she worked on the flea, Uropsylla tasmanica, which is a flea that infects quolls and Tasmanian devils.[1] CareerPearse worked in the Cytogenetics Laboratory at the Royal Hobart Hospital, Tasmania for seventeen years where she worked on human leukemia but also continued studying quolls.[1][2][3] During this period she published work on cancer in quolls.[4] She initially retired from scientific work, establishing a flower farm, before returning to science to work on DFTD.[5] She joined the Save the Tasmanian Devil program at the Department of Primary Industries, Parks, Water and Environment, Tasmanian Government, in 2004 after hearing about the disease on the radio.[1][3] In 2006, Pearse and her colleague Swift published a paper on their findings on DFTD in Nature.[6] In their report they studied tumours from eleven Tasmanian devils. They observed that the tumours had major chromosomal abnormalities and these abnormalities were the same between individual animals. This led them to conclude that the tumour cells in different animals were of the same clonal origin. As a result they proposed the hypothesis that "the disease is transmitted by allograft, whereby an infectious cell line is passed directly between the animals through bites they inflict on one another.".[6] Since then, other scientists have added further evidence to the Allograft Theory of DFTD whilst Pearse has continued to uncover new information on the disease.[7] Awards and honours
References1. ^1 2 3 4 {{Cite web|url=https://www.jfcr.or.jp/princehitachiprize/e/2012.html|title=The Prince Hitachi Prize for Comparative Oncology {{!}} 2012 Awardee|last=|first=|date=|website=www.jfcr.or.jp|archive-url=|archive-date=|dead-url=|access-date=2019-03-23}} 2. ^{{Cite journal|last=Melrose|first=W. D.|last2=Pearse|first2=A. M.|last3=Bell|first3=P. A.|last4=Jupe|first4=D. M.|last5=Baikie|first5=M. J.|last6=Twin|first6=J. E.|last7=Bryant|first7=S. L.|date=1990|title=Haematology of the Australian eastern quoll, Dasyurus viverrinus--II. Red cell enzymes and metabolic intermediates|journal=Comparative Biochemistry and Physiology. B, Comparative Biochemistry|volume=97|issue=1|pages=47–48|issn=0305-0491|pmid=2147643|doi=10.1016/0305-0491(90)90175-S}} 3. ^1 {{Cite web|url=http://discovermagazine.com/2014/may/13-the-immortal-devil|title=Fatal Cancer Threatens Tasmanian Devil Populations {{!}} DiscoverMagazine.com|website=Discover Magazine|access-date=2019-03-23}} 4. ^{{Cite journal|last=Twin|first=J. E.|last2=Pearse|first2=A. M.|date=1986|title=A malignant mixed salivary tumour and a mammary carcinoma in a young wild eastern spotted native cat Dasyurus viverrinus (Marsupialia)|journal=Journal of Comparative Pathology|volume=96|issue=3|pages=301–306|issn=0021-9975|pmid=3013953|doi=10.1016/0021-9975(86)90050-2}} 5. ^{{Cite news|url=https://harpers.org/archive/2008/04/contagious-cancer/5/|title=Contagious Cancer|last=Quammen|first=David|date=2008|work=Harper's Magazine|access-date=2019-03-23|issn=0017-789X}} 6. ^1 {{Cite journal|last=K. Swift|last2=Pearse|first2=A.-M.|date=2006-02-02|title=Allograft theory: Transmission of devil facial-tumour disease|journal=Nature|language=en|volume=439|issue=7076|pages=549|doi=10.1038/439549a|pmid=16452970|issn=1476-4687}} 7. ^{{Cite journal|last=Pye|first=R. J.|last2=Woods|first2=G. M.|last3=Kreiss|first3=A.|date=2015-12-13|title=Devil Facial Tumor Disease|journal=Veterinary Pathology|volume=53|issue=4|pages=726–736|doi=10.1177/0300985815616444|issn=1544-2217|pmid=26657222}} 8. ^{{Cite web|url=https://www.theaustralian.com.au/higher-education/the-22nd-annual-australian-museum-eureka-prizes/news-story/a5e330766658b2343582c40a9516bd18|title=Eureka! All the winners|date=2011-09-06|website=www.theaustralian.com.au|access-date=2019-03-23}} 5 : Living people|Australian scientists|Cytogenetics|Women scientists|Year of birth missing (living people) |
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