| 词条 | Hepatitis B virus PRE 1151-1410 |
| 释义 |
| Name = Hepatitis B virus PRE 1151-1410 | image = RF02816.svg | width = | caption = Predicted secondary structure and sequence conservation of Hepatitis B virus PRE 1151-1410 | Symbol = | AltSymbols = | Rfam = RF02816 | miRBase = | miRBase_family = | RNA_type = | Tax_domain = Viruses | GO = {{GO|0051168}},{{GO|0043484}} | SO = {{SO|0005836}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }}Hepatitis B virus PRE 1151-1410 (HBV post-transcriptional regulatory element, nucleotides 1151-1410) is a part of 500 base pair long HBV PRE, that has been proposed to be the HBV RNA export element.[1][2][3] However, the function is controversial and new regulatory elements have been predicted within PRE.[4] PRE 1151-1410 enhances nuclear export of intronless transcripts and represses the splicing mechanism to a comparable degree to that of the full-length PRE. Hence it was proposed to be the core HBV PRE element.[4] PRE1151-1410 contains 3 known regulatory elements: PRE SL-alpha (nucleotides 1292-1321),[5] human La protein binding site (nucleotide 1275-1291),[6] SRE-1 (nucleotides 1252-1348).[7] See also
References1. ^{{Cite journal|last=Panjaworayan|first=Nattanan|last2=Roessner|first2=Stephan K.|last3=Firth|first3=Andrew E.|last4=Brown|first4=Chris M.|date=2007-12-17|title=HBVRegDB: annotation, comparison, detection and visualization of regulatory elements in hepatitis B virus sequences|journal=Virology Journal|volume=4|pages=136|doi=10.1186/1743-422X-4-136|issn=1743-422X|pmc=2235840|pmid=18086305}} {{molecular-cell-biology-stub}}2. ^{{Cite journal|last=Huang|first=J.|last2=Liang|first2=T. J.|date=December 1993|title=A novel hepatitis B virus (HBV) genetic element with Rev response element-like properties that is essential for expression of HBV gene products|journal=Molecular and Cellular Biology|volume=13|issue=12|pages=7476–7486|issn=0270-7306|pmid=8246965}} 3. ^{{Cite journal|last=Huang|first=Z. M.|last2=Yen|first2=T. S.|date=May 1994|title=Hepatitis B virus RNA element that facilitates accumulation of surface gene transcripts in the cytoplasm|journal=Journal of Virology|volume=68|issue=5|pages=3193–3199|issn=0022-538X|pmid=8151782}} 4. ^1 {{Cite journal|last=Visootsat|first=Akasit|last2=Payungporn|first2=Sunchai|last3=T-Thienprasert|first3=Nattanan P.|date=December 2015|title=A conserved RNA structural element within the hepatitis B virus post-transcriptional regulatory element enhance nuclear export of intronless transcripts and repress the splicing mechanism|journal=Molecular Biology Reports|volume=42|issue=12|pages=1603–1614|doi=10.1007/s11033-015-3928-0|issn=1573-4978|pmid=26514143}} 5. ^{{Cite journal|last=Panjaworayan|first=Nattanan|last2=Payungporn|first2=Sunchai|last3=Poovorawan|first3=Yong|last4=Brown|first4=Chris M.|date=2010-09-08|title=Identification of an effective siRNA target site and functional regulatory elements, within the hepatitis B virus posttranscriptional regulatory element|journal=Virology Journal|volume=7|pages=216|doi=10.1186/1743-422X-7-216|issn=1743-422X|pmc=2945954|pmid=20822550}} 6. ^{{Cite journal|last=Ehlers|first=Imke|last2=Horke|first2=Sven|last3=Reumann|first3=Kerstin|last4=Rang|first4=Andreas|last5=Grosse|first5=Frank|last6=Will|first6=Hans|last7=Heise|first7=Tilman|date=2004-10-15|title=Functional characterization of the interaction between human La and hepatitis B virus RNA|journal=The Journal of Biological Chemistry|volume=279|issue=42|pages=43437–43447|doi=10.1074/jbc.M402227200|issn=0021-9258|pmid=15302879}} 7. ^{{Cite journal|last=Heise|first=Tilman|last2=Sommer|first2=Gunhild|last3=Reumann|first3=Kerstin|last4=Meyer|first4=Imke|last5=Will|first5=Hans|last6=Schaal|first6=Heiner|date=2006|title=The hepatitis B virus PRE contains a splicing regulatory element|journal=Nucleic Acids Research|volume=34|issue=1|pages=353–363|doi=10.1093/nar/gkj440|issn=1362-4962|pmc=1331995|pmid=16410615}} 2 : RNA|Non-coding RNA |
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