| 词条 | Immunological constant of rejection |
| 释义 |
The Immunologic Constant of Rejection (ICR), is a set of genes that is involved in tissue destruction along a diverse set of physiological circumstances like autoimmune disease or allograft rejection or pathological conditions like infection and cancer.[1] Important geneset within the ICR consist of:[2]
In several cancers these genes show great correlation,[3][4] a high expression of these genes indicates an active immune engagement and, at least a partial rejection of the cancer tissue. This phenotype is associated with a better prognosis and thus longer survival time.[4][3][2] In breast cancer the increased survival time observed in patients displaying a high level of ICR gene expression was found to be associated with increased level of mutation of the tumor tissue while the poor immune phenotype was defined by perturbation in the MAPK signalling pathways.[5] References1. ^{{Cite journal|last=Wang|first=Ena|last2=Worschech|first2=Andrea|last3=Marincola|first3=Francesco M.|title=The immunologic constant of rejection|journal=Trends in Immunology|volume=29|issue=6|pages=256–262|doi=10.1016/j.it.2008.03.002|pmid=18457994|year=2008}} 2. ^1 {{Cite journal|last=Galon|first=Jérôme|last2=Angell|first2=Helen K.|last3=Bedognetti|first3=Davide|last4=Marincola|first4=Francesco M.|title=The Continuum of Cancer Immunosurveillance: Prognostic, Predictive, and Mechanistic Signatures|journal=Immunity|volume=39|issue=1|pages=11–26|doi=10.1016/j.immuni.2013.07.008|pmid=23890060|year=2013}} 3. ^1 2 {{Cite journal|last=Bedognetti|first=Davide|last2=Hendrickx|first2=Wouter|last3=Marincola|first3=Francesco M.|last4=Miller|first4=Lance D.|title=Prognostic and predictive immune gene signatures in breast cancer|url=http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00001622-201511000-00003|journal=Current Opinion in Oncology|volume=27|issue=6|pages=433–444|doi=10.1097/cco.0000000000000234|pmid=26418235|year=2015}} 4. ^1 2 {{Cite journal|last=Bedognetti|first=Davide|last2=Hendrickx|first2=Wouter|last3=Ceccarelli|first3=Michele|last4=Miller|first4=Lance D|last5=Seliger|first5=Barbara|title=Disentangling the relationship between tumor genetic programs and immune responsiveness|journal=Current Opinion in Immunology|volume=39|pages=150–158|doi=10.1016/j.coi.2016.02.001|pmid=26967649|year=2016}} 5. ^{{Cite journal|last=Hendrickx|first=Wouter|last2=Simeone|first2=Ines|last3=Anjum|first3=Samreen|last4=Mokrab|first4=Younes|last5=Bertucci|first5=François|last6=Finetti|first6=Pascal|last7=Curigliano|first7=Giuseppe|last8=Seliger|first8=Barbara|last9=Cerulo|first9=Luigi|date=2017-02-06|title=Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis|journal=OncoImmunology|volume=0|issue=2|pages=e1253654|doi=10.1080/2162402X.2016.1253654|pmid=28344865|issn=2162-402X|pmc=5353940}} 1 : Immunology |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。