“2-oxoaldehyde dehydrogenase (NAD+)”的意思、由来-开放百科全书

词条

2-oxoaldehyde dehydrogenase (NAD+)

释义

References

{{enzyme
| Name = 2-oxoaldehyde dehydrogenase (NAD)
| EC_number = 1.2.1.23
| CAS_number = 37250-91-2
| IUBMB_EC_number = 1/2/1/23
| GO_code = 0047551
| image =
| width =
| caption =
}}

In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) ({{EC number|1.2.1.23}}) is an enzyme that catalyzes the chemical reaction

a 2-oxoaldehyde + NAD⁺ + H₂O a 2-oxo acid + NADH + H⁺

The 3 substrates of this enzyme are 2-oxoaldehyde, NAD⁺, and H₂O, whereas its 3 products are 2-oxo acid, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NAD+ 2-oxidoreductase. Other names in common use include alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NAD+-linked alpha-ketoaldehyde dehydrogenase, 2-ketoaldehyde dehydrogenase, NAD+-dependent alpha-ketoaldehyde dehydrogenase, and 2-oxoaldehyde dehydrogenase (NAD+). This enzyme participates in pyruvate metabolism.

References

{{cite journal | author = Monder C | date = 1967 | title = Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate | journal = J. Biol. Chem. | volume = 242 | pages = 4603–9 | pmid = 4383524 | issue = 20 }}
{{cite journal |vauthors=Ray M, Ray S | date = 1982 | title = On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase | journal = J. Biol. Chem. | volume = 257 | pages = 10571–4 | pmid = 7107626 | issue = 18 }}
{{cite journal |vauthors=Ray S, Ray M | date = 1982 | title = Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate | journal = J. Biol. Chem. | volume = 257 | pages = 10566–70 | pmid = 7107625 | issue = 18 }}

3 : EC 1.2.1|NADH-dependent enzymes|Enzymes of unknown structure

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