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Loftus is a surname. Notable people with the surname include: - Adam Loftus (Archbishop) (1533–1605), Irish Archbishop, Lord Chancellor of Ireland, first provost of Trinity College, Dublin
- Adam Loftus, 1st Viscount Loftus (1568–1643), Lord Chancellor of Ireland in 1619
- Aisling Loftus (1990–), English actress
- Amy Loftus, American singer
- Dudley Loftus (died 1616) (1561-1616), an Irish landowner and politician
- Cecilia Loftus (1876–1943), Scottish burlesque performer and actress
- Elizabeth Loftus (born 1944), American psychologist and author
- Hubert J. Loftus (1924-1995), American politician
- John Loftus (born 1950), American author, former US government prosecutor, and former Army intelligence officer
- Johnny Loftus (1895–1976), American horse racing jockey
- Joseph Philip Loftus, Assistant Director at the Johnson Space Center, Senior 1000 Government Official
- Loftus Dudley Ward, Canadian naval chief petty officer elected to the Legislative Assembly of Alberta in 1945
- Loftus William Jones (1879–1916), English recipient of the Victoria Cross
- Lord Augustus Loftus (Lord Augustus William Frederick Spencer Loftus) (1817–1909), Governor of New South Wales, Australia 1879–1885
- Ruben Loftus-Cheek (born 1996), English football player
- Seán Dublin Bay Rockall Loftus (1927–2010), Irish barrister, politician, and environmentalist
- Thomas Loftus (1917-2011), former Chairman of Leinster Gaelic Athletic Association
- Tom Loftus (1856–1910), American professional baseball player and manager
- William Loftus (1820–1858), British geologist, naturalist, explorer, and archaeological excavator
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