| 词条 | Multiomics |
| 释义 |
}} Multiomics refers to a biological analysis approach in which the data sets are multiple "omes", such as the genome, proteome, transcriptome, epigenome, and microbiome;[1][2][3] in other words, the use of multiple omics technologies to study life in a concerted way. By combining these omes into a set of omes, scientists can analyze complex biological big data efficiently enough to easily find relevant biomarkers. In so doing, multiomics integrates diverse omics data to find a coherently matching geno-pheno-envirotype relationship or association, even with reduced numbers of samples, although multiomics usually involves 'big' data. Usually, a very large number of samples is required to detect functional relationships, but, using multiomics, encompassing multiple data types, researchers try to detect such associations with more confidence. A possible example case would be suicide biomarker detection by taking the blood of depressive patients and performing genomic, transcriptomic, and epigenomic sequencing, combining these omes to find significant markers from the case population. References1. ^{{cite journal|last1=Bersanelli|first1=Matteo|last2=Mosca|first2=Ettore|last3=Remondini|first3=Daniel|last4=Giampieri|first4=Enrico|last5=Sala|first5=Claudia|last6=Castellani|first6=Gastone|last7=Milanesi|first7=Luciano|title=Methods for the integration of multi-omics data: mathematical aspects|journal=BMC Bioinformatics|date=1 January 2016|volume=17|issue=2|pages=S15|doi=10.1186/s12859-015-0857-9|url=https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-015-0857-9|accessdate=31 October 2016|issn=1471-2105|pmid=26821531|pmc=4959355}} 2. ^{{cite journal|last1=Bock|first1=Christoph|last2=Farlik|first2=Matthias|last3=Sheffield|first3=Nathan C.|title=Multi-Omics of Single Cells: Strategies and Applications|journal=Trends in Biotechnology|date=August 2016|volume=34|issue=8|pages=605–608|doi=10.1016/j.tibtech.2016.04.004|url=http://www.cell.com/trends/biotechnology/fulltext/S0167-7799(16)30023-3|accessdate=31 October 2016}} 3. ^{{cite journal|last1=Vilanova|first1=Cristina|last2=Porcar|first2=Manuel|title=Are multi-omics enough?|journal=Nature Microbiology|date=26 July 2016|volume=1|issue=8|pages=16101|doi=10.1038/nmicrobiol.2016.101|url=http://www.nature.com/articles/nmicrobiol2016101|accessdate=31 October 2016}} See also
1 : Biology theories |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。