| 词条 | Neovasculgen |
| 释义 |
| gt_target_gene = delivers new VEGF | gt_vector = | gt_nucleic_acid_type = | gt_editing_method = | gt_delivery_method = | drug_name = | INN = | pronounce = | tradename = Neovasculgen | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = | pregnancy_category= | routes_of_administration = Intraneural injection | legal_AU = | legal_AU_comment = | legal_CA = | legal_DE = | legal_NZ = | legal_UK = | legal_US = | legal_UN = | legal_status = | bioavailability = | protein_bound = | metabolism = | metabolites = | onset = | elimination_half-life = | duration_of_action = | excretion = | CAS_number = | class = | ATCvet = | ATC_prefix = V03 | ATC_suffix = AX | PubChem = | ChemSpiderID = none | DrugBank = | synonyms = Pl-VEGF165 | chemical_formula = | molecular_weight = }} Neovasculgen is a gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia; it delivers the gene encoding for vascular endothelial growth factor (VEGF).[1][2] Neovasculogen is a plasmid encoding the CMV promoter and the 165 amino acid form of VEGF.[3][4] It was developed by the Human Stem Cells Institute in Russia and approved in Russia in 2011. References1. ^AdisInsight Vascular endothelial growth factor gene therapy - HSCI Page accessed 5 June 2016 2. ^{{cite news|url=http://www.dddmag.com/news/2011/12/gene-therapy-pad-approved|title=Gene Therapy for PAD Approved|date=6 December 2011|accessdate=5 August 2015}} 3. ^Eurolab. Neovasculogen listing in Eurolab Page accessed 4 August 2015 4. ^{{cite journal|last2=Bozo|first2=I.|last3=Mzhavanadze|first3=N.|last4=Voronov|first4=D.|last5=Gavrilenko|first5=A.|last6=Chervyakov|first6=Yu.|last7=Staroverov|first7=I.|last8=Kalinin|first8=R.|last9=Shvalb|first9=P.|date=13 March 2015|title=pCMV-vegf165 Intramuscular Gene Transfer is an Effective Method of Treatment for Patients With Chronic Lower Limb Ischemia|journal=Journal of cardiovascular pharmacology and therapeutics|volume=20|issue=5|pages=473–82|doi=10.1177/1074248415574336|pmid=25770117|last1=Deev|first1=R.|last10=Isaev|first10=A.}} See also
1 : Gene therapy |
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