词条 | Philip Scheltens |
释义 |
Philip Scheltens (born 1957) is a Dutch professor of neurology and Director of the Alzheimer Centre, VU University Medical Center Amsterdam. Early life, education and careerPhilip Scheltens was born in Dordrecht, Netherlands, where he grew up in a family of four. His father led a factory and played an active role in the local society. His grandfather developed Alzheimer’s disease in those years, which made an important impression on his grandson. Philip attended the Christelijk Lyceum, where he graduated in 1976. As a teenager he was an enthusiastic drummer in several bands and fostered a fascination for science and mechanics. After his graduation, he studied medicine at the Vrije Universiteit (VU) Amsterdam, while working night hours as a portiere in a famous Amsterdam nightclub, where he met many Dutch celebrities. He obtained his medical degree in 1984 and started his career in neurology. During his PhD he developed MRI criteria to score hippocampus atrophy for the diagnosis of Alzheimer’s disease. AchievementsScheltens’ work has changed the way Alzheimer’s disease is diagnosed. While diagnosis used to be based on specific signs and symptoms and exclusion of treatable causes, he was the first to add MRI criteria for hippocampal atrophy, associated with Alzheimer’s’ disease in the 1990s, which improved the diagnostic classification of this type of dementia and fueled development of new diagnostics. He was one of the first in the Netherlands to start a dementia clinic and started the Amsterdam Dementia cohort, currently the largest collection of clinical and biomarker data. This enabled him to initiate, together with colleagues, new diagnostic research criteria for Alzheimer’s disease based on the presence of a clinical phenotype and the presence of amyloid, as reflected in cerebrospinal fluid. This change from a phenomenological, purely symptom driven, diagnosis to a diagnosis based on biomarkers greatly enhanced sensitivity and specificity. Higher diagnostic precision is the crucial step to develop effective therapy, as patients with homogeneous underlying pathology can be included for therapeutic trials targeting the causative mechanism. The new protein-based diagnostic criteria he fathered are now implemented for trials worldwide and the first hopeful results have emerged. Scheltens has improved societal awareness and acceptance of dementia, and prioritized dementia among the top necessities on the Dutch and European research agenda. He initiated a large scientific and societal action plan to improve prevention, treatment and care for dementia in the Netherlands, entitled Deltaplan Dementie in 2012, which has already supported a large number of research projects on dementia, increased societal awareness and improved health care for dementia patients. In 2011 Scheltens became a member of the Royal Netherlands Academy of Arts and Sciences.[1] In November 2018 Expertscape recognized Dr. Scheltens as #6 in the world for expertise in Alzheimer's Disease. [2] Present occupation and academic tasks1991–present: Staff neurologist 2000–present: Full Professor of (Cognitive) Neurology 2000–present: Director of the Alzheimer Centre, VU University Medical Center Amsterdam. 2008–present: Management team Neuroscience Campus Amsterdam 2013–present: vice-chair Board of Directors Dutch “Deltaplan Dementie” (2013-2021). Co-editor-in-chief of the series: Current Issues in Neurodegenerative Disorders Member editorial board Dementia Geriatric Cognitive Disorders, Alzheimer’s Disease & Associated Disorders, Int J geriatric Psychiatry, J NeuroImaging, Chief Editor supplement to Dementia Geriatr Cogn Disord entitled ‘White matter disease’ Associate editor of J Neurol Neurosurgery Psychiatry Co-editor-in-chief, Alzheimer's Research & Therapy[3] 2012–present Member Supervisory Board Hersenstichting Nederland 2012-2015 Member International Scientific Program Committee AAIC Member Scientific Advisory Council ISTAART 2013–present Member of the jury of the BRAIN PRIZE (Grete Lundbeck Foundation)[4] 2015–present Member Program Committee EAN annual conference 2015–present Board member Dutch Academy of Science and Arts (KNAW)[5] PublicationsScheltens has authored or coauthored over 700 publications, from which some frequently cited studies are listed below.[6]
References1. ^{{cite web|author= |url=https://www.knaw.nl/en/members/members/11669?set_language=en |title=Philip Scheltens |publisher=Royal Netherlands Academy of Arts and Sciences |date= |accessdate=15 November 2015}} {{Authority control}}{{DEFAULTSORT:Scheltens, Philip}}2. ^{{cite web|url=http://www.expertscape.com/the-leaders/alzheimer+disease |title=Expertscape: Alzheimer Disease, November 2018 |publisher=expertscape.com |date=November 2018 |accessdate=2018-11-15 }} 3. ^{{cite web|title=Alzheimer's Research & Therapy|url=http://www.alzres.com/|publisher=BioMed Central Ltd|accessdate=October 25, 2015}} 4. ^{{cite web|title=Philip Scheltens|url=http://www.thebrainprize.org/flx/selection_committee/philip_scheltens/|publisher=Grete Lundbeck European Brain Research Prize|accessdate=October 25, 2015}} 5. ^{{cite web|title=Academy Board|url=https://www.knaw.nl/en/about-us/organisatie/bestuur|publisher=Royal Netherlands Academy of Arts and Sciences|accessdate=October 25, 2015}} 6. ^{{PubMedAuthorSearch|Scheltens|P}} 7 : 1957 births|Living people|Dutch neurologists|Members of the Royal Netherlands Academy of Arts and Sciences|People from Dordrecht|Vrije Universiteit Amsterdam alumni|Vrije Universiteit Amsterdam faculty |
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