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词条 Proser1
释义

  1. Nomenclature

  2. Gene

     Location  Gene neighborhood  Tissue distribution 

  3. Homology

     Paralogs  Orthologs 

  4. Protein

     General properties  Composition  Domains  Secondary structure 

  5. References

{{Infobox gene}}PROSER1 is a protein that in humans is encoded by the PROSER1 gene.[1]

Nomenclature

PROSER1 has several aliases: C13orf23, KIAA2032, and proline and serine-rich protein 1.[2]

[3]

Gene

Location

PROSER1 is located on the negative (reverse) strand of chromosome 13 at position 13q13.3. It spans from 39,009,865 base pairs from the pter to 39,038,095 bp from the pter, with a size of 28,231 bases.[4] PROSER1 has a total of 13 exons in its primary unspliced transcript mRNA of 5,185 bp. There are 2 isoforms of PROSER1, both within the 5,000 bp range.[5]

Gene neighborhood

Genes STOML3 and NHLRC3 neighbor PROSER1 on chromosome 13.[6]

Tissue distribution

Expressed Sequence Tag mapping of PROSER1 expression shows that it has particularly high expression in lymph, embryonic tissue, thymus, and uterus sites. It has moderate expression in testis, larynx, nerve, blood, and adipose tissue sites.[7]

According to the Human Protein Atlas, PROSER1 has general cytoplasmic expression and is expressed in all RNA tissue categories.[8]

Homology

Paralogs

PROSER1 has no paralogs.[9]

Orthologs

PROSER1 is highly conserved among mammals. It is less highly conserved, though has been found, in fish, birds, and some invertebrates. It is not expressed in bacteria, plants, or fungi.[10] Show below is table of orthologs compiled from NCBI.

Latin name Common name Date of divergence (from H. sapiens) Accession number Protein sequence length Sequence identity Sequence similarity
Homo sapiens Human - NP_079414.3 944 amino acids - -
Gorilla gorilla Gorilla 8.9 million years ago XP_004054459 994 aa 99% 99%
Colobus angolensis palliatus Angola colobus 29.1 MYA XP_011798372 947 aa 97% 97%
Nannospalax galili Spalax 90.9 MYA XP_008847583 916 aa 80% 85%
Cricetulus griseus Chinese Hamster 90.9 MYA XP_007626898 912 aa 79% 84%
Panthera tigris altaica Siberian Tiger 97.5 MYA XP_007097793 665 aa 85% 89%
Acinonyx jubatus Cheetah 97.5 MYA XP_014926409 770 aa 79% 83%
Tursiops truncatus Common Bottlenose Dolphin 97.5 MYA XP_004332367 1064 aa 77% 83%
Ornithorhynchus anatinus Platypus 179.2 MYA XP_007666895 888 aa 69% 74%
Chelonia mydas Green Sea Turtle 320.5 MYA XP_007070970 936 aa 75% 83%
Pygoscelis adeliae Adelie Penguin 320.5 MYA XP_009318201 938 aa 75% 83%
Calidris (philomachus) pugnax Ruff 320.5 MYA XP_014821534 899 aa 74% 83%
Chrysemys picta bellii Painted Turtle 320.5 MYA XP_008175998 825 aa 73% 82%
Aquila chrysaetos Canadensis Golden Deagle 320.5 MYA XP_011579121 916 aa 73% 81%
Alligator sinensis Chinese Alligator 320.5 MYA XP_014376376 940 aa 72% 81%
Gekko japonicus Japanese Gecko 320.5 MYA XP_015281837 1053 aa 65% 75%
Python bivittatus Burmese Python 320.5 MYA XP_007438154 924 aa 65% 75%
Anolis carolinensis Carolina Anole 320.5 MYA XP_008124125 920 aa 64% 75%
Xenopus tropicalis Western Clawed Frog 355.7 MYA XP_012813331 944 aa 51% 63%
Lepisosteus oculatus Spotted Gar 429.6 MYA XP_015197497 885 aa 47% 58%
Callorhinchus milii Australian Ghost Shark 482.9 MYA XP_007889503 965 aa 64% 75%

Protein

General properties

The translated PROSER1 protein is 944 amino acids long. Its predicted molecular weight is 95.7 kdal.[11] PROSER1 has an isoelectric point of 9.[12] It is predicted to be localized to the nucleus.[13]

Composition

The sequence is rich in proline and serine and not particularly low in any other amino acids.

Domains

PROSER1 contains one domain of unknown function, DUF 4476, part of pfam14771. The DUF spans from amino acids 26 to 121.[https://www.ncbi.nlm.nih.gov/protein/125656155?report=fasta]

The molecular weight of DUF 4476 is 11.1 kdal.

Secondary structure

PROSER1 is composed primarily of alpha helices, beta sheets, and coils. The protein is largely coiled. The DUF is composed mainly of alpha helices and coils. It has slightly fewer beta sheets compared to the protein as a whole.[14]

References

1. ^{{cite web|title=GeneCards|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=PROSER1|publisher=Human Gene Database}}
2. ^{{cite web|title=BioCompare|url=http://www.biocompare.com/9776-Antibodies/7476873-PROSER1-NT-PROSER1-C13orf23-KIAA2032-Proline-and-serine-rich-protein-1/?ncatid=9776&ppim=7476873_0_0|publisher=BioCompare}}
3. ^{{cite web|title=Ensembl|url=http://useast.ensembl.org/Homo_sapiens/Transcript/Summary?db=core;g=ENSG00000120685;r=13:39022354-39026472;t=ENST00000496138|publisher=Ensembl}}
4. ^{{cite web|title=GeneCards|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=PROSER1|publisher=Human Gene Database}}
5. ^{{cite web|title=NCBI Gene|url=https://www.ncbi.nlm.nih.gov/gene/80209|publisher=NCBI}}
6. ^{{cite web|title=NCBI Gene|url=https://www.ncbi.nlm.nih.gov/gene/80209|publisher=NCBI}}
7. ^{{cite web|title=Uniprot|url=https://www.uniprot.org/uniprot/Q86XN7|publisher=Uniprot}}
8. ^{{cite web|title=Tissue Atlas|url=http://www.proteinatlas.org/ENSG00000120685-PROSER1/tissue|publisher=The Human Protein Atlas}}
9. ^{{cite web|title=Ensembl|url=http://useast.ensembl.org/Homo_sapiens/Transcript/Summary?db=core;g=ENSG00000120685;r=13:39022354-39026472;t=ENST00000496138|publisher=Ensembl}}
10. ^{{cite web|title=Ensembl|url=http://useast.ensembl.org/Homo_sapiens/Transcript/Summary?db=core;g=ENSG00000120685;r=13:39022354-39026472;t=ENST00000496138|publisher=Ensembl}}
11. ^{{cite web|title=Uniprot|url=https://www.uniprot.org/uniprot/Q86XN7|publisher=Uniprot}}
12. ^{{cite web|title=Expasy|url=http://web.expasy.org/compute_pi/|publisher=Expasy}}
13. ^{{cite web|title=PSORT II Prediction|url=http://psort.hgc.jp/form2.html|publisher=PSORT II}}
14. ^{{cite web|title=SDSC Biology Workbench|url=http://workbench.sdsc.edu/|publisher=SDSC}}
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