| 词条 | Amlodipine/benazepril |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 415479203 | image = Amlodipine.svg | image2 = Benazepril.svg | type = combo | component1 = Amlodipine | class1 = Calcium channel blocker | component2 = Benazepril | class2 = ACE inhibitor | tradename = | pregnancy_AU = | pregnancy_US = D | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = Rx-only | legal_status = | routes_of_administration = By mouth | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 357437-90-2 | ATC_prefix = None | ATC_suffix = | PubChem = 5746247 | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4676979 | KEGG = D11069 }}Amlodipine/benazepril, marketed as Lotrel among others, is a medication used to treat high blood pressure.[1] It is a combination of amlodipine, a calcium channel blocker and benazepril, a angiotensin converting enzyme inhibitor.[1] It may be used if a single agent is not sufficient.[1] It is taken by mouth.[1] Common side effects include cough, dizziness, and swelling.[1] Serious side effects may include angioedema, myocardial infarction, high blood potassium, liver problems, and low blood pressure.[1] Use in pregnancy is not recommended.[1] Amlodipine works by increasing the size of arteries while benazepril works by decreasing renin-angiotensin-aldosterone system activity.[1] The combination was approved for medical use in the United States in 1995.[2] It is available as a generic medication.[3] A month supply in the United States has a wholesale cost of about 4.50 USD.[4] In 2016 it was the 140th most prescribed medication in the United States with more than 4 million prescriptions.[5] Medical useIt is used to treat high blood pressure.[1] It is not a first line treatment.[6] References1. ^1 2 3 4 5 6 7 8 {{cite web |title=DailyMed - AMLODIPINE BESYLATE AND BENAZEPRIL HYDROCHLORIDE- amlodipine besylate and benazepril hydrochloride capsule |url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=df8e23c8-6c8f-4293-8a37-5ad3d48dba94 |website=dailymed.nlm.nih.gov |accessdate=10 March 2019}} 2. ^{{cite web |title=Amlodipine and benazepril Uses, Side Effects & Warnings |url=https://www.drugs.com/mtm/amlodipine-and-benazepril.html |website=Drugs.com |accessdate=10 March 2019 |language=en}} 3. ^{{cite book |last1=Bope |first1=Edward T. |last2=Kellerman |first2=Rick D. |title=Conn's Current Therapy 2017 E-Book |date=2016 |publisher=Elsevier Health Sciences |isbn=9780323443357 |page=124 |url=https://books.google.ca/books?id=UitFDQAAQBAJ&pg=PT158 |language=en}} 4. ^{{cite web |title=NADAC as of 2019-02-27 |url=https://data.medicaid.gov/Drug-Pricing-and-Payment/NADAC-as-of-2019-02-27/s7c9-pfa6 |website=Centers for Medicare and Medicaid Services |accessdate=3 March 2019 |language=en}} 5. ^{{cite web |title=The Top 300 of 2019 |url=https://clincalc.com/DrugStats/Top300Drugs.aspx |website=clincalc.com |accessdate=22 December 2018}} 6. ^{{cite journal |last1=Faulkner |first1=MA |last2=Hilleman |first2=DE |title=Amlodipine/benazepril: fixed dose combination therapy for hypertension. |journal=Expert opinion on pharmacotherapy |date=January 2001 |volume=2 |issue=1 |pages=165-78 |doi=10.1517/14656566.2.1.165 |pmid=11336577}} External links
5 : Combination drugs|Novartis|Novartis brands|Prodrugs|RTT |
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