| 词条 | Trichosporon asteroides |
| 释义 |
| name = Trichosporon asteroides | image = Trichosporon asteroides culture.jpg | image_alt = | image_caption = | regnum = Fungi | divisio = Basidiomycota | classis = Tremellomycetes | ordo = Tremellales | genus = Trichosporon | species = T. asteroides | binomial = Trichosporon asteroides | binomial_authority = M. Ota (1926) | synonyms = *Parendomyces asteroides Rischin (1921)
}}Trichosporon asteroides is an asexual Basidiomycetous fungus first described from human skin but is now mainly isolated from blood and urine.[1][2][3][4][5] T. asteroides is a hyphal fungus with a characteristically yeast-like appearance due to the presence of slimy arthroconidia.[3][7] Infections by this species usually respond to treatment with azoles and amphotericin B.[2][9][10] History and taxonomyTrichosporon asteroides was isolated from lesion of male chin skin by Rinchin in Berne in 1926 and named in the genus, Parendomyces. T. asteroides was later reevaluated by Masao Ota and transferred to the genus Trichosporon as T. asteroides.[1] Ota noted that its hyphae were more sparsely branched than other species in Trichosporon, and it lacked the ability to ferment glucose, maltose, sucrose and fructose.[1] Molecular phylogenetic study has since supported the placement of T. asteroides in the genus Trichsporon.[13] T. asteroides was determined to be conspecific with Fissuricella filamenta on the basis of DNA/DNA reassociation.[3][7] Modern classifications support the affiliation of this species with the order Tremellales in the phylum Basidiomycota.[16]Growth and morphologyT. asteroides grows in a range of media including in the presence of the antifungal agent, cycloheximide.[4] Colonies of T. asteroides grown on Sabouraud agar appear white in colour with a brain-like texture, reaching a diameter of 10 mm after 10 days growth at {{convert|25|C|F}}.[3][7] Colonies have radially furrowed outer zone and matt appearance that is not powdery like the related species, T. asahii.[3] Antibodies produced by infected patients can also be used to differentiate T. asahii and T. asteroides in disease. Weak growth is seen at {{convert|37|C|F}} but is absent at higher temperatures.[7][16] T. asteroides can be distinguish with other relative species in the genus Trichosporon by its ability to utilize D-galactose, L-rhamnose, erythritol and L-arabinitol.[3]Physiology and pathogenesisT. asteroides does not ferment glucose, maltose, sucrose or fructose, this is the common feature to all the species in Trichosporon.[1] T. asteroides causes trichosporonosis, which mainly responsible for deep-seated, mucosa-associated, superficial, and systematic infections including blood.[2][4][7][29][30] This species is one of the three most common Trichosporon species isolated in clinical settings.[29] The fungus is sometimes recovered from specimens of blood, urine, and aspiration fluid, vaginal mucosa, male perigenital skin area, and catheters.[4][33][5] The first record of this agent in a systemic infection involved a bloodstream infection.[4] Some main types of latent infection can be raised are fungemia, urinary tract infections, peritonitis, endocarditis, arthritis, esophagitis, meningitis, brain abscess, splenic abscess, and uterine infections.[2] Allergies and systemic infections can also be caused by this fungus particularly in immunosuppressed people.[37] Recently, T. asteroides was implicated in a case of kerion celsi, a rare, highly inflammatory scalp infection seen mainly in children.[38]This fungus is rarely encountered in zoonotic infections[37] and has never been shown to cause disease un insects.[29] However, T. asteroides was isolated from the multifocal, irregularly raised skin lesions on a female Bottle-Nosed Dolphin, Tursiops truncatus, in Japan.[37] In the absence of cultures and molecular biological analysis, the agent was initially suspected to be Paracoccidioides ceti, a worldwide causative agent of Paracoccidioidomycosis in dolphins.[37] TreatmentAzole antifungals are often used as a front-line therapy in trichosporonosis.[9] Resistance to amphotericin, flucytosine, fluconazole, and itraconazole have been described.[10][2] Echinocandins, as a group, are ineffective against Trichosporon species.[7] Triazoles show better in vitro and in vivo antifungal activity than amphotericin B, while voriconazole also has excellent in vitro activity against Trichosporon asteroides.[2][10][49] Combination therapy regimens such as voriconazole and amphotericin B are also effective in serious infections.[49] Fluconazole has been used successfully in subcutaneous and deep infections.[38] References1. ^1 {{cite journal |last1=Sugita |first1=Takashi |last2=Nakase |first2=Takashi |title=Molecular phylogenetic study of the basidiomycetous anamorphic yeast genus Trichosporon and related taxa based on small subunit ribosomal DNA sequences |journal=Mycoscience |date=1998 |volume=39 |issue=1 |pages=7–13 |doi=10.1007/BF02461572 }} [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]2. ^1 2 3 4 5 6 {{cite journal |last1=Guého |first1=E. |last2=Smith |first2=M. T. |last3=De Hoog |first3=G. S. |last4=Billon-Grand |first4=G. |last5=Christen |first5=R. |last6=van der Vegte |first6=W. B. |title=Contributions to a revision of the genus Trichosporon |journal=Antonie van Leeuwenhoek |date=1992 |volume=61 |issue=4 |pages=289–316 |doi= 10.1007/BF00713938}} 3. ^1 2 3 4 5 6 {{cite journal |last1=Guého |first1=Eveline |last2=Improvisi |first2=Luce |last3=Dupont |first3=B. |last4=De Hoog |first4=G. S. |title=Trichosporon on humans: a practical account: Trichosporon am Menschen: Eine Darstellung für die Praxis. |journal=Mycoses |date=1994 |volume=37 |issue=1–2 |pages=3–10 |doi=10.1111/j.1439-0507.1994.tb00277.x }} 4. ^1 2 {{cite book |last1=Howard |first1=Dexter H. |title=Pathogenic fungi in humans and animals |date=2007 |publisher=Marcel Dekker |location=New York |isbn=9780203909102 |edition=2nd |language=en}} 5. ^1 2 3 4 5 {{cite journal |last1=Kustimur |first1=Semra |last2=Kalkanci |first2=Ayse |last3=Caglar |first3=Kayhan |last4=Dizbay |first4=Murat |last5=Aktas |first5=Firdevs |last6=Sugita |first6=Takashi |title=Nosocomial fungemia due to Trichosporon asteroides: firstly described bloodstream infection |journal=Diagnostic Microbiology and Infectious Disease |date=2002 |volume=43 |issue=3 |pages=167–170 |doi=10.1016/S0732-8893(02)00385-1}} 6. ^1 2 3 4 {{cite journal |last1=Masao |first1=Ota |title=Sur quelques champignons pathogènes du type Trichosporum beigeli Vuillemin |journal=Annales de Parasitologie Humaine et Comparée |date=1926 |volume=4 |issue=1 |pages=1–13 |doi=10.1051/parasite/1926041001 }} 7. ^1 2 3 {{cite journal |last1=Mariné |first1=Marçal |last2=Bom |first2=Vinicius Leite Pedro |last3=Castro |first3=Patricia Alves de |last4=Winkelstrote |first4=Lizziane Kretli |last5=Ramalh |first5=Leandra Naira |last6=Brown |first6=Neil Andrew |last7=Goldman |first7=Gustavo Henrique |title=The development of animal infection models and antifungal efficacy assays against clinical isolates of Trichosporon asahii, T. asteroides and T. inkin |journal=Virulence |date=2015 |volume=6 |issue=5 |pages=476–86 |doi=10.1080/21505594.2015.1020273 |pmid=25751127 |pmc=4601256 }} 8. ^1 {{cite journal |last1=Sugita |first1=T |last2=Nishikawa |first2=A |last3=Shinoda |first3=T |title=Rapid detection of species of the opportunistic yeast Trichosporon by PCR. |journal=Journal of Clinical Microbiology |date=1998 |volume=36 |issue=5 |pages=1458–60 |pmid=9574732|pmc=104855 }} 9. ^1 {{cite journal |last1=Paula |first1=Claudete R. |last2=Krebs |first2=Vera L. J. |last3=Auler |first3=Marcos E. |last4=Ruiz |first4=Luciana S. |last5=Matsumoto |first5=Flavia E. |last6=Silva |first6=Elza H. |last7=Diniz |first7=Edna M. A. |last8=Vaz |first8=Flavio A. C. |title=Nosocomial infection in newborns by in a Brazilian intensive care unit |journal=Medical Mycology |date=2006 |volume=44 |issue=5 |pages=479–484 |doi=10.1080/13693780600561809|pmid=16882616 }} 10. ^1 2 {{cite journal |last1=Silvestre Junior |first1=Agenor Messias |last2=Miranda |first2=Mauricio Alexandre Bandeira Rampazzo |last3=Camargo |first3=Zoilo Pires de |title=Trichosporon species isolated from the perigenital region, urine and catheters of a Brazilian population |journal=Brazilian Journal of Microbiology |date=2010 |volume=41 |issue=3 |pages=628–34 |doi=10.1590/S1517-83822010000300013 |pmid=24031538 |pmc=3768649 }} 11. ^1 2 3 4 {{cite journal |last1=Ueda |first1=Keiichi |last2=Nakamura |first2=Ichiro |last3=Itano |first3=Eiko Nakagawa |last4=Takemura |first4=Kazunori |last5=Nakazato |first5=Yasutomo |last6=Sano |first6=Ayako |title=Trichosporon asteroides Isolated from Cutaneous Lesions of a Suspected Case of "paracoccidioidomycosis ceti" in a Bottlenose Dolphin (Tursiops truncatus) |journal=Mycopathologia |date=2017 |volume=182 |issue=9–10 |pages=937–946 |doi=10.1007/s11046-017-0147-3 |pmid=28547342 }} 12. ^1 2 3 4 5 6 {{cite journal |last1=Colombo |first1=A. L. |last2=Padovan |first2=A. C. B. |last3=Chaves |first3=G. M. |title=Current Knowledge of Trichosporon spp. and Trichosporonosis |journal=Clinical Microbiology Reviews |date=2011 |volume=24 |issue=4 |pages=682–700 |doi=10.1128/CMR.00003-11|pmid=21976604 |pmc=3194827 }} 13. ^1 2 {{cite journal |last1=Kocabaş |first1=Bilge Aldemİr |last2=Karbuz |first2=Adem |last3=Çİftçİ |first3=Ergin |last4=Beğde |first4=Fırat |last5=Ametoglou |first5=Selver |last6=Fouad |first6=Ali Adil |last7=Kalkancı |first7=Ayşe |last8=Karahan |first8=Zeynep Ceren |last9=Aysev |first9=Derya |last10=İnce |first10=Erdal |title=Trichosporon asteroides: A novel etiologic agent of Kerion celsi in a child |journal=İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi |date=2016 |volume=6 |issue=2 |pages=151–154 |url=http://www.journalagent.com/behcetuz/pdfs/BUCHD_6_2_151_154.pdf}} 14. ^1 2 {{cite journal |last1=Anaissie |first1=E. |last2=Gokaslan |first2=A. |last3=Hachem |first3=R. |last4=Rubin |first4=R. |last5=Griffin |first5=G. |last6=Robinson |first6=R. |last7=Sobel |first7=J. |last8=Bodey |first8=G. |title=Azole Therapy for Trichosporonosis: Clinical Evaluation of Eight Patients, Experimental Therapy for Murine Infection, and Review |journal=Clinical Infectious Diseases |date=1992 |volume=15 |issue=5 |pages=781–787 |doi=10.1093/clind/15.5.781 |language=en |issn=1058-4838}} 15. ^1 2 {{cite journal |last1=Maxfield |first1=Luke |last2=Matthews |first2=Juliana J. |last3=Ambrosetti |first3=David Ryan |last4=Ephtimios |first4=Issa E. |title=Trichosporon fungemia in a pediatric patient with acute lymphoblastic leukemia |journal=IDCases |date=2015 |volume=2 |issue=4 |pages=106–108 |doi=10.1016/j.idcr.2015.09.007 |pmid=26793473 |pmc=4712209 |issn=2214-2509}} 16. ^1 2 3 {{cite journal |last1=Garg |first1=Vaibhav |last2=Jones |first2=Elizabeth K. |last3=Friedman |first3=Ben J. |last4=Lee |first4=Jason B. |last5=Yang |first5=Sherry |title=Invasive trichosporonosis treated with voriconazole |journal=JAAD Case Reports |date=2018 |volume=4 |issue=4 |pages=362–364 |doi=10.1016/j.jdcr.2017.11.003 |pmid=29693071 |pmc=5911819 |issn=2352-5126}} }}{{taxobar | from = Q10703238}} 2 : Tremellomycetes|Fungi described in 1926 |
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