Upson is a surname. Notable people with the surname include:

• Arthur Upson, American poet
• Charles Upson, U.S. Representative from Michigan
• Christopher C. Upson, U.S. Representative from Texas
• Donna Upson, Canadian white supremacist
• Jill Upson, American politician
• Matthew Upson, English football player
• Maxwell Upson, trustee of Cornell University
• Ralph Hazlett Upson, American balloonist
• Stephen Upson, American politician and lawyer
• William Hazlett Upson, American author

• List of Presidents of the Senate of Antigua and Barbuda
• List of Presidents of the Senate of Barbados
• List of Presidents of the Senate of Belize
• List of Presidents of the Senate of Bermuda
• List of Presidents of the Senate of Burundi
• List of Presidents of the Senate of Colombia
• List of Presidents of the Senate of Eswatini
• List of Presidents of the Senate of Gabon
• List of Presidents of the Senate of Grenada
• List of Presidents of the Senate of Jamaica
• List of Presidents of the Senate of Jordan
• List of Presidents of the Senate of Lesotho
• List of Presidents of the Senate of Madagascar
• List of Presidents of the Senate of Mauritania
• List of Presidents of the Senate of Paraguay
• List of Presidents of the Senate of Saint Lucia
• List of Presidents of the Senate of Senegal
• List of Presidents of the Senate of the Bahamas
• List of Presidents of the Senate of the Czech Republic
• List of Presidents of the Senate of the Republic of the Congo
• List of Presidents of the Senate of Uruguay
• List of Presidents of the Soviet Union
• List of presidents of the states
• List of presidents of the Statistical Society of Canada
• List of Presidents of the Storting